Diametric calix[6]arene gold(<scp>i</scp>) catalysts for intramolecular cyclopropanations of 1,6-dienynes

Cera, Gianpiero; Balestri, Davide; Secchi, Andrea; Giovanardi, Gabriele

doi:10.1039/d2ob01074g

Cited by 4 publications

(1 citation statement)

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“…In 2023, Cera and co‐workers reported the synthesis of inherently chiral calix[4]arenes 15 in their racemic forms through gold(I)‐catalyzed intramolecular hydroarylation of alkynes 14 [25] (Scheme 6). Notably, a preliminary study of the catalytic enantioselective version of this reaction was attempted, which produced the inherently chiral calix[4]arenes 15 a in 98 % yield with 28 % ee in the presence of a chiral phosphoramidite ligand, validating the proof of concept of this catalytic asymmetric approach.…”

Section: Catalytic Enantioselective Synthesis Of Inherently Chiral Ca...mentioning

confidence: 99%

Catalytic Enantioselective Synthesis of Inherently Chiral Molecules: Recent Advances

Tang,

Yang

2023

Eur J Org Chem

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Inherent chirality represents a distinct category of molecular chirality that does not fall within the traditional classification of four chiral elements: central, axial, planar, and helical chirality. While extensive research has been conducted on the catalytic enantioselective construction of these conventional chiralities, the corresponding synthesis of inherently chiral molecules has remained largely unexplored. This minireview provides a comprehensive summary of recent advancements in this field, focusing on the catalytic asymmetric synthesis of inherently chiral calixarenes, saddle‐shaped tetraphenylenes and their heterocycle derivatives, mechanically planar chiral rotaxanes and chiral multilayer 3D frameworks, as well as our perspective in this field.

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Section: Catalytic Enantioselective Synthesis Of Inherently Chiral Ca...mentioning

confidence: 99%