Diamine oxidase activity levels in anorexia nervosa

Abstract

DAO levels were decreased in AN-R patients. This finding suggests the presence of intestinal structural disturbance as one of the physical complications of malnutrition in AN-R patients.

Gastrointestinal complications associated with anorexia nervosa: A systematic review

“…Whereas impaired functionality has not been demonstrated, a controlled study (21 ANR; 15 AN‐BP; 20 controls) found that diamine oxidase, a marker for intestinal villi integrity and maturity, was significantly reduced in patients with ANR. Whereas this reflects the importance of food exposure to the health of the intestinal villi, the lack of functional measures precluded correlations of diamine oxidase levels with intestinal permeability as had been suggested in other animal and human studies …”

“…Whereas this reflects the importance of food exposure to the health of the intestinal villi, the lack of functional measures precluded correlations of diamine oxidase levels with intestinal permeability as had been suggested in other animal and human studies. 161 Intestinal transit times/constipation. In a descriptive study of radiologic findings in 50 patients with AN, Haller et al 162 noted transient non-obstructive mild jejunal dilatation in one-third of the cases and that small bowel transit ranged from normal to occasionally delayed although no case-specific information was included.…”

Integrating anatomo‐physiological changes and pharmacogenomics in anti‐infective therapy management: is it a major concern?

“…Its pharmacokinetics may be affected by anorexia nervosa, which leads to body composition alterations. Anatomo-functional changes of intestinal mucosa occur in this situation leading to a significant mucosal atrophy [3]. Thus, anorexia nervosa reduces absorption and intestinal permeability [4], possibly explaining the very low VRC exposure observed in this patient during oral treatment but not the failure of the intravenous therapy.…”

Serum diamine oxidase activity as a predictor of gastrointestinal toxicity and malnutrition due to anticancer drugs

“…reported that DAO activity in the blood significantly correlates with DAO activity in the tissues of the small intestine in animals . Several studies have been reported in which DAO activity was measured and small intestinal lesions were assessed in patients with inflammatory bowel disease, acute mesenteric ischemia, and other diseases . However, there have been only a few reports on the relationship between DAO activity and anticancer‐drug‐induced mucosal damage .…”

“…11 Several studies have been reported in which DAO activity was measured and small intestinal lesions were assessed in patients with inflammatory bowel disease, acute mesenteric ischemia, and other diseases. [12][13][14][15][16] However, there have been only a few reports on the relationship between DAO activity and anticancer-drug-induced mucosal damage. [17][18][19] Moriyama et al measured serum DAO activity in rats, comparing gastrointestinal damage between the group receiving S-1 containing potassium oxonate (Oxo) (which reduces gastrointestinal damage) and the group receiving S-1 without Oxo.…”