Diamine‐Promoted Deacylation of 2‐Alkyl‐1,3‐Diketones for the Facile Synthesis of Ketones

Abstract

A facile synthesis of ketones was developed based on the diamine‐promoted deacylation of 2‐alkyl‐1,3‐diketones. More specifically, 2‐alkyl‐1‐arylbutane‐1,3‐diones were efficiently deacylated in the presence of 2,2‐dimethylpropane‐1,3‐diamines to afford the corresponding aryl ketones with a high regioselectivity. Notably, this regioselectivity was different from that observed under the conventional retro‐Claisen conditions.