Diamond and Diamond-like Carbon Coated Surfaces as Biomaterials

Lackner, J.M.; Waldhauser, W.

doi:10.1007/s00501-010-0613-4

Cited by 11 publications

(11 citation statements)

References 80 publications

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“…[7][8][9][10][11][12]. Additionally, a-C:H film coating has emerged as a potential technique for blood interfacing applications [7][8][9]. Several recent attempts were made to modify the characteristics of a-C:H coating by adding elements, such as O, N, and F, into the films [13,14].…”

Section: Introductionmentioning

confidence: 99%

“…It was observed that the a-C:H film coating enhanced cell growth. As well known, application of carbon coatings for medical engineering has indicated that it is promising for improvement of biomaterials [7][8][9][10][11][12]. Especially, a-C:H film coating is one of materials of highest biocompatibility and often used as medical devices.…”

Section: Introductionmentioning

confidence: 99%

“…a-C:H film including diamond-like carbon (DLC) has low frictional coefficient, high wear and corrosion resistance, chemical inertness, high electrical resistivity, infrared-transparency, high refractive index, and excellent smoothness, etc. [7][8][9][10][11][12]. Additionally, a-C:H film coating has emerged as a potential technique for blood interfacing applications [7][8][9].…”

Section: Introductionmentioning

confidence: 99%

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Investigation of biocompatibility on nitrogen-doped a-C:H film coating scaffold surface in in-vivo and in-vitro tests

et al. 2013

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Investigation of biocompatibility on nitrogen-doped a-C:H film coating scaffold surface in in-vivo and in-vitro tests

et al. 2013

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“…Such DLC coatings are generally amorphous and are characterized by a mixture of sp 2 and sp 3 hybridized carbon atoms and, mostly, hydrogen (a-C:H). However, physical and chemical influences on their biocompatibility have not yet been fully solved, as described in a review on about 90 different DLC materials [19]. Nevertheless, the cytotoxicity of DLC materials is very low with no in vitro effects on mouse macrophages, human fibroblasts, monocytes, osteoblasts [20,21] even under in vivo conditions in subcutaneous, bone and muscle tissue in guinea pig [22], sheep and rat models [23]).…”

Section: Introductionmentioning

confidence: 99%

Gas Permeation, Mechanical Behavior and Cytocompatibility of Ultrathin Pure and Doped Diamond-Like Carbon and Silicon Oxide Films

et al. 2013

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Protective ultra-thin barrier films gather increasing economic interest for controlling permeation and diffusion from the biological surrounding in implanted sensor and electronic devices in future medicine. Thus, the aim of this work was a benchmarking OPEN ACCESSCoatings 2013, 3 269 of the mechanical oxygen permeation barrier, cytocompatibility, and microbiological properties of inorganic ~25 nm thin films, deposited by vacuum deposition techniques on 50 µm thin polyetheretherketone (PEEK) foils. Plasma-activated chemical vapor deposition (direct deposition from an ion source) was applied to deposit pure and nitrogen doped diamond-like carbon films, while physical vapor deposition (magnetron sputtering in pulsed DC mode) was used for the formation of silicon as well as titanium doped diamond-like carbon films. Silicon oxide films were deposited by radio frequency magnetron sputtering. The results indicate a strong influence of nanoporosity on the oxygen transmission rate for all coating types, while the low content of microporosity (particulates, etc.) is shown to be of lesser importance. Due to the low thickness of the foil substrates, being easily bent, the toughness as a measure of tendency to film fracture together with the elasticity index of the thin films influence the oxygen barrier. All investigated coatings are non-pyrogenic, cause no cytotoxic effects and do not influence bacterial growth.

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“…a-C:H films have also shown promising results in hemocompatible coating technology. To date many types of a-C:H films have been applied to medical devices [17][18][19][20][21][22][23][24].…”

Section: Introductionmentioning

confidence: 99%

Improved Hemolytic Performance of Blood Pump with Fluorine-Doped Hydrogenated Amorphous Carbon Coating

Ohgoe

Hiratsuka²,

Sumikura³

et al. 2013

ACES

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Fluorine-doped hydrogenated amorphous carbon (a-C:H:F) film was deposited on a flow-straightener, impeller and diffuser surface (SUS 304) of an enclosed-impeller type flow blood pump using the ionization deposition method with a source gas of C₆F₅H. The surface characteristics of the a-C:H:F film were examined using atomic force microscopy, X-ray photoelectron spectroscopy, and measurements of surface roughness, friction and surface potential. The a-C:H:F film tends to increase surface roughness and the negative surface charge. In addition, the surface energy and friction decrease with fluorine dopant in the a-C:H film. To estimate the hemolytic performance of a blood pump with the a-C:H:F film coating, the amount of hemolysis was measured using a mock circulatory system (in vitro test) with 500 mL of pig blood containing sodium citrate. In vitro test was conducted for 180 min with the blood flow and pump head maintained at 5 L/min and 100 mmHg, respectively. The a-C:H:F film coating reduced the amount of hemolysis and improved the hemolytic performance. Decreasing the surface energy and negative surface charge of the a-C:H:F film contributes to the improvement of the hemolytic performance. The a-C:H:F film coating is thus expected to be utilized in medical technology as a surface coating technology for artificial heart blood pumps.

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Diamond and Diamond-like Carbon Coated Surfaces as Biomaterials

Cited by 11 publications

References 80 publications

Investigation of biocompatibility on nitrogen-doped a-C:H film coating scaffold surface in in-vivo and in-vitro tests

Investigation of biocompatibility on nitrogen-doped a-C:H film coating scaffold surface in in-vivo and in-vitro tests

Gas Permeation, Mechanical Behavior and Cytocompatibility of Ultrathin Pure and Doped Diamond-Like Carbon and Silicon Oxide Films

Improved Hemolytic Performance of Blood Pump with Fluorine-Doped Hydrogenated Amorphous Carbon Coating

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