Diamond-Blackfan anemia and nutritional deficiency-induced anemia in children

Abstract

Diamond-Blackfan anemia is a rare, inherited disease that characteristically presents as a chronic, normochromic macrocytosis due to red cell lineage bone marrow failure. Although studies are elaborating on the genetic basis for its associated comorbidities, little has been published comparing this anemia to other chronic anemias that have similar laboratory results in children. This article offers a global perspective of the disease and compares it with anemia due to vitamin B12 and folate deficiency in children.

Evaluation of Macrocytic Anemias

“…46 Patients with Diamond-Blackfan anemia may be macrocytic, and it is important to consider this diagnosis in anemic children with MCV above normal for age. 47 A more recently recognized cause of macrocytic anemia is copper deficiency. Copper deficiency has been diagnosed more frequently recently due to the increased number of surgeries being performed for morbid obesity.…”

Effect of nutritional supplement on bone marrow-derived mesenchymal stem cells from aplastic anaemia

“…Yu et al ( 19 ) showed that the appropriate vitamin D supplementation could partly correct the immune dysfunction by strengthening signal transduction through vitamin D receptor in patients with AA. DBA was also associated with higher serum levels of vitamin B 12 and folate, which would provide an efficient method for ruling out these deficiencies in the investigation of chronic anaemia ( 20 ) . Given that a single or a complex of several micronutrients supplementation is helpful in the recuperation process of AA, we prepared NS according to a novel formula of nutrient mixture with thirty-six ingredients, including different amino acids, nucleotide, vitamin, folate, soyabean phospholipid, inositol, iron, zinc, manganese, etc., which was added in the daily diet of AA rats, subsequently the effect and underlying mechanism were explored.…”