Diamond-like carbon coatings with Ca-O-incorporation for improved biological acceptance

Dorner-Reisel, Annett; Schürer, Christian; Irmer, G.; Simon, Frank; Nischan, Claudia; Müller, Eberhard

doi:10.1007/s00216-002-1546-x

Cited by 16 publications

(1 citation statement)

References 8 publications

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“…The adhesion of the DLC coating to metallic substrates can be improved by ion etching of the substrate surface prior to the actual coating process, since this removes the passivating oxide layers [31]. As DLC coatings exhibit intrinsic residual stresses induced by the high-energy coating processes [32], the coating thickness influences to a large extend the adhesion and the tendency to spallation or delamination as well as the formation of wear particles [33]. Increasing the hydrogen content in the DLC layer can also lessen residual stresses and promote adhesion but reduces hardness.…”

Section: Introductionmentioning

confidence: 99%

Amorphous Carbon Coatings for Total Knee Replacements—Part I: Deposition, Cytocompatibility, Chemical and Mechanical Properties

et al. 2021

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Diamond-like carbon (DLC) coatings have the potential to reduce implant wear and thus to contribute to avoiding premature failure and increase service life of total knee replacements (TKAs). This two-part study addresses the development of such coatings for ultrahigh molecular weight polyethylene (UHMWPE) tibial inlays as well as cobalt–chromium–molybdenum (CoCr) and titanium (Ti64) alloy femoral components. While a detailed characterization of the tribological behavior is the subject of part II, part I focusses on the deposition of pure (a‑C:H) and tungsten-doped hydrogen-containing amorphous carbon coatings (a‑C:H:W) and the detailed characterization of their chemical, cytological, mechanical and adhesion behavior. The coatings are fabricated by physical vapor deposition (PVD) and display typical DLC morphology and composition, as verified by focused ion beam scanning electron microscopy and Raman spectroscopy. Their roughness is higher than that of the plain substrates. Initial screening with contact angle and surface tension as well as in vitro testing by indirect and direct application indicate favorable cytocompatibility. The DLC coatings feature excellent mechanical properties with a substantial enhancement of indentation hardness and elastic modulus ratios. The adhesion of the coatings as determined in modified scratch tests can be considered as sufficient for the use in TKAs.

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Section: Introductionmentioning

confidence: 99%

Amorphous Carbon Coatings for Total Knee Replacements—Part I: Deposition, Cytocompatibility, Chemical and Mechanical Properties

et al. 2021

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Laser Processing of Advanced Bioceramics

et al. 2005

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In this article, laser processing of diamondlike carbon‐metal nanocomposite films, hydroxyapatite‐osteoblast composites, and Ormocer® microdevices for medical applications is described. Pulsed laser deposition has been used to process diamondlike carbon‐silver‐platinum nanocomposite films that provide hardness, wear resistance, corrosion resistance, and antimicrobial functionalities to cardiovascular, orthopaedic, biosensor, and MEMS devices. Laser direct writing has been used for fabricating integrated cell‐scaffold structures. Two photon induced polymerization has been used to create Ormocer® tissue engineering scaffolds and microneedles with unique geometries. Pulsed laser deposition, laser direct write, and two photon induced polymerization techniques may provide medical engineers with advanced biomaterials that possess unique structures and functionalities.

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In situ endothelialization of intravascular stents from progenitor stem cells coated with nanocomposite and functionalized biomolecules

Motwani¹,

Rafiei²,

Tzifa³

et al. 2011

Biotech and App Biochem

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Abstract.Owing to their noninvasive nature, coronary artery stents have become popular demand for patients undergoing percutaneous coronary intervention. Late restenosis, in-stent restenosis, and late thrombosis, all mediated by the denuded endothelium, represent the most recurrent failures of vascular stent induction. Higher patency rates of stents can be achieved by restoring the native internal environment of the vessel-an endothelium monolayer. This active organ inhibits the inflammatory reaction to injury responsible for thrombus and intimal hyperplasia, thereby providing a novel therapeutic option to combat the unacceptably high prevalence of restenosis. As the climax of the nanotechnology era approaches, tissue engineering is being explored by means of exploiting the multipotent abilities of stem cells and their adherence to bioactive surface nanocomposite polymers. The endothelium can be reconstructed from neighboring intact endothelium and adherence of circulating endothelium progenitor cells. The latter takes place via a series of signaling events: mobilization, adhesion, chemoattraction, migration, proliferation, and finally their differentiation in mature endothelial cells. A nanotopography surface can orchestrate endothelium formation, attributable to cellular interactions promoted by its nanosize. This review encompasses the prospect of in situ endothelialization, the mechanisms regulating the process, and the advantages of using a new generation of bioactive nanocomposite materials for coating metal stent scaffolds.

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Diamond-like carbon coatings with Ca-O-incorporation for improved biological acceptance

Cited by 16 publications

References 8 publications

Amorphous Carbon Coatings for Total Knee Replacements—Part I: Deposition, Cytocompatibility, Chemical and Mechanical Properties

Amorphous Carbon Coatings for Total Knee Replacements—Part I: Deposition, Cytocompatibility, Chemical and Mechanical Properties

Laser Processing of Advanced Bioceramics

In situ endothelialization of intravascular stents from progenitor stem cells coated with nanocomposite and functionalized biomolecules

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