diaPASEF analysis for HLA-I peptides enables quantification of common cancer neoantigens
Denys Oliinyk,
Hem Gurung,
Zhenru Zhou
et al.
Abstract:Human leukocyte antigen class I (HLA-I) molecules present short peptide sequences from endogenous or foreign proteins to cytotoxic T cells. The low abundance of HLA-I peptides poses significant technical challenges for their identification and accurate quantification. While mass spectrometry (MS) is currently a method of choice for direct system-wide identification of cellular immunopeptidome, there is still a need for enhanced sensitivity in detecting and quantifying tumor specific epitopes. As gas phase sepa… Show more
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