DIAPH2, PTPRD and HIC1 Gene Polymorphisms and Laryngeal Cancer Risk

Śnit, Mirosław; Misiołek, Maciej; Ścierski, Wojciech; Koniewska, Anna; Stryjewska-Makuch, Grażyna; Okła, Sławomir; Grzeszczak, W

doi:10.3390/ijerph18147486

Cited by 7 publications

(7 citation statements)

References 24 publications

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“…The N-terminal BTB/POZ domain of HIC1 is responsible for protein-protein interactions, and the C-terminal zinc finger domains contribute to sequence-specific binding to an HIC1-responsive element (HiRE) through a TGCC (A/C) core motif [ 19 ]. As HIC1 is usually hypermethylated or deleted in several types of human tumors and promotes tumor progression, it is now known as a tumor growth regulator and tumor repressor [ 20 – 22 ]. Constitutive knockout of Hic1 often leads to embryonic lethality [ 23 ], whereas heterozygous mice often develop various spontaneous malignant tumors [ 24 ].…”

Section: Introductionmentioning

confidence: 99%

Targeting HIC1/TGF-β axis-shaped prostate cancer microenvironment restrains its progression

Wang

Shi

et al. 2022

Cell Death Dis

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Prostate cancer (PCa) is a malignant tumor that seriously threatens men’s health worldwide. Recently, stromal cells in the tumor microenvironment (TME) have been reported to contribute to the progression of PCa. However, the role and mechanism of how PCa cells interact with stromal cells to reshape the TME remain largely unknown. Here, using a spontaneous prostate adenocarcinoma (PRAD) model driven by the loss of Pten and Hic1, we found that M2 macrophages markedly infiltrated the stroma of Pten and Hic1 double conditional knockout (dCKO) mice compared with those in control (Ctrl) mice due to higher TGF-β levels secreted by HIC1-deleted PCa cells. Mechanistically, TGF-β in TME promoted the polarization of macrophages into “M2” status by activating the STAT3 pathway and modulating c-Myc to upregulate CXCR4 expression. Meanwhile, TGF-β activated the fibroblasts to form cancer-associated fibroblasts (CAFs) that secrete higher CXCL12 levels, which bound to its cognate receptor CXCR4 on M2 macrophages. Upon interaction with CAFs, M2 macrophages secreted more CXCL5, which promoted the epithelial-mesenchymal transition (EMT) of PCa via CXCR2. Moreover, using the TGF-β receptor I antagonist, galunisertib, significantly inhibited the tumor growth and progression of the TRAMP-C1 cell line-derived subcutaneous tumor model. Finally, we confirmed that the stromal microenvironment was shaped by TGF-β in HIC1-deficient PCa and was associated with the progression of PCa.

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Section: Introductionmentioning

confidence: 99%

Targeting HIC1/TGF-β axis-shaped prostate cancer microenvironment restrains its progression

Wang

Shi

et al. 2022

Cell Death Dis

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“…Gastroesophageal reflux disease is another risk factor, as chronic acid reflux can damage the laryngeal lining, leading to cellular changes and increased cancer risk [ 13 - 15 ]. Genetic susceptibility plays a role as well, with certain genetic polymorphisms, such as those in the DIAPH2 , PTPRD , and HIC1 genes, being associated with an increased risk of laryngeal cancer [ 16 ]. Additionally, a poor diet, particularly a low intake of fruits and vegetables, can impair the body’s ability to repair DNA damage and maintain healthy cellular functions, further increasing cancer risk [ 14 , 15 ].…”

Section: Discussionmentioning

confidence: 99%

Insights From the National Inpatient Sample (2016–2019) on Laryngeal Cancer Incidence and Trends

Albazee,

Alharran,

Alzayed

et al. 2024

Cureus

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Background: Laryngeal cancer has a significant impact on speech, swallowing, and quality of life. This study aims to analyze laryngeal cancer trends using the National Inpatient Sample (NIS) database, providing insights into its epidemiology.Methods: Data from the NIS database was analyzed for a cohort of 14,282 laryngeal cancer cases from 2016 to 2019. Baseline characteristics and demographic parameters, including primary expected payer, age groups, hospital types, and geographic regions, were examined. Descriptive statistics and trend analysis were conducted.Results: The cohort showed consistent annual case numbers (range: 3739-3948). The highest case numbers were in the 40-64 age group (average 1998 cases/year), followed by the 65-80 age group (average 1473 cases/year). Medicare was the most common primary expected payer, followed by Medicaid, private insurance, self-pay, and no charge. The cohort was roughly three times more skewed toward males, with an average of 2936 male cases per year compared to 885 female cases. Notable trends included significant positive correlations with time for urban teaching hospitals, the South region, older age group (65-80 years), and Asian or Pacific Islander individuals. However, the overall correlation between case numbers and time was not statistically significant. The primary expected payer and deaths exhibited moderate correlations with time but did not reach statistical significance. Conclusion:This study provides insights into the baseline characteristics and trends in laryngeal cancer incidence. The observed demographic shifts highlight the need for further investigation into underlying factors influencing case distribution. Understanding these trends can guide targeted interventions for prevention, early detection, and treatment of laryngeal cancer.

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“…DIAPH2 expression plays an important role in invadopodia formation and is required for tumor cell invasion ( Yang et al, 2007 ; Lizárraga et al, 2009 ). DIAPH2 alterations increase cellular motility and may contribute to the onset and metastasis of laryngeal cancer ( Kostrzewska-Poczekaj et al, 2019 ; Śnit et al, 2021 ). To our knowledge, no clinical study has investigated the role of DIAPH2 in PAAD.…”

Section: Discussionmentioning

confidence: 99%

“…DIAPH2 and DIAPH3 are required for invadopodia formation and tumor cell invasion ( Lizárraga et al, 2009 ). DIAPH2 alterations increase cellular motility and may contribute to the onset and metastasis of laryngeal cancer ( Kostrzewska-Poczekaj et al, 2019 ; Śnit et al, 2021 ). DIAPH3 is highly expressed in tissues of patients with pancreatic cancer, lung adenocarcinoma, and hepatocellular carcinoma ( Dong et al, 2018 ; Xiang et al, 2019 ; Rong et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Diaphanous-related formin subfamily: Novel prognostic biomarkers and tumor microenvironment regulators for pancreatic adenocarcinoma

Zhang

et al. 2022

Front. Mol. Biosci.

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The diaphanous-related formin subfamily includes diaphanous homolog 1 (DIAPH1), DIAPH2, and DIAPH3. DIAPHs play a role in the regulation of actin nucleation and polymerization and in microtubule stability. DIAPH3 also regulates the assembly and bipolarity of mitotic spindles. Accumulating evidence has shown that DIAPHs are anomalously regulated during malignancy. In this study, we reviewed The Cancer Genome Atlas database and found that DIAPHs are abundantly expressed in pancreatic adenocarcinoma (PAAD). Furthermore, we analyzed the gene alteration profiles, protein expression, prognosis, and immune reactivity of DIAPHs in PAAD using data from several well-established databases. In addition, we conducted gene set enrichment analysis to investigate the potential mechanisms underlying the roles of DIAPHs in the carcinogenesis of PAAD. Finally, we performed the experimental validation of DIAPHs expression in several pancreatic cancer cell lines and tissues of patients. This study demonstrated significant correlations between DIAPHs expression and clinical prognosis, oncogenic signature gene sets, T helper 2 cell infiltration, plasmacytoid dendritic cell infiltration, myeloid-derived suppressor cell infiltration, ImmunoScore, and immune checkpoints in PAAD. These data may provide important information regarding the role and mechanisms of DIAPHs in tumorigenesis and PAAD immunotherapy.

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DIAPH2, PTPRD and HIC1 Gene Polymorphisms and Laryngeal Cancer Risk

Cited by 7 publications

References 24 publications

Targeting HIC1/TGF-β axis-shaped prostate cancer microenvironment restrains its progression

Targeting HIC1/TGF-β axis-shaped prostate cancer microenvironment restrains its progression

Insights From the National Inpatient Sample (2016–2019) on Laryngeal Cancer Incidence and Trends

Diaphanous-related formin subfamily: Novel prognostic biomarkers and tumor microenvironment regulators for pancreatic adenocarcinoma

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