1978
DOI: 10.1136/thx.33.4.483
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Diaphragm and body weight in emphysema.

Abstract: Thurlbeck, W M (1978). Thorax, 33,[483][484][485][486][487] Diaphragm and body weight in emphysema. The weight of the diaphragm has been investigated in 103 male patients and 81 female patients, and the relationship between body weight and emphysema has been assessed in 662 male and 431 female patients. Diaphragm weight is related to body weight in both male (r= +0 76) and female patients (r= +0 77) and is relatively larger in the former. Dissecting the diaphragm free of fat or freeze drying it does not apprec… Show more

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Cited by 141 publications
(42 citation statements)
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“…In rats the effect of undernutrition has been shown to be greater on fast-twitch (type 2) fibres than on slow-twitch (type 1) fibres (Lewis et al 1987). Thurlbeck's (1978) study on diaphragm weight implies that respiratory muscle wasting may be an important effect of malnutrition. This post-mortem study of 184 emphysematous patients found that diaphragm weight was lower than expected for body weight, probably because respiratory muscle consists of a higher proportion of type 2 fibres than peripheral muscle and these are relatively more affected by undernutrition than type 1 fibres.…”
Section: Mortality and Morbiditymentioning
confidence: 99%
“…In rats the effect of undernutrition has been shown to be greater on fast-twitch (type 2) fibres than on slow-twitch (type 1) fibres (Lewis et al 1987). Thurlbeck's (1978) study on diaphragm weight implies that respiratory muscle wasting may be an important effect of malnutrition. This post-mortem study of 184 emphysematous patients found that diaphragm weight was lower than expected for body weight, probably because respiratory muscle consists of a higher proportion of type 2 fibres than peripheral muscle and these are relatively more affected by undernutrition than type 1 fibres.…”
Section: Mortality and Morbiditymentioning
confidence: 99%
“…In patients with chronic obstructive pulmonary disease (COPD), diaphragm muscle mass and thickness vary with body weight in a fashion similar to that of patients without chronic pulmonary disease [16]. In addition, patients with greater degrees of emphysema had more severe reduction of body and diaphragm weight.…”
Section: Diaphragm Musclementioning
confidence: 98%
“…COPD patients are frequently undernourished [5] and their diaphragmatic muscle mass is reduced in even greater proportion than their body weight [6]. Furthermore, corticosteroids are still often used on a long term basis in COPD despite their well known adverse effects.…”
Section: Consequences Of Load/capacity Imbalancementioning
confidence: 99%