Diaphragmatic function is markedly altered in cerulein-induced pancreatitis

Cerulein-induced diaphragmatic dysfunction was attributable, in part, to nitric oxide overproduced via inducible nitric oxide synthase. Pretreatment with ONO-1714 at a dose of 0.1 mg/kg attenuated diaphragmatic dysfunction associated with cerulein-induced pancreatitis in rats assessed by contractile profiles and endurance capacity. This beneficial effect of ONO-1714 may be attributable, in part, to inhibition of diaphragmatic lipid peroxidation induced by nitric oxide-derived free radicals.

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Diaphragmatic function is markedly altered in cerulein-induced pancreatitis

Abstract: Acute pancreatitis induced marked diaphragmatic dysfunction. Although the precise mechanisms responsible for this alteration are not precisely determined, diaphragmatic dysfunction may play a role in pancreatitis-associated respiratory failure.

Cited by 6 publications

References 14 publications

Organ Failure and Prediction of Severity in Acute Pancreatitis

Organ Failure and Prediction of Severity in Acute Pancreatitis

Pulmonary complications of acute pancreatitis

ONO-1714, a new inducible nitric oxide synthase inhibitor, attenuates diaphragmatic dysfunction associated with cerulein-induced pancreatitis in rats

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