Diaphragmatic motor cortex hyperexcitability in patients with chronic obstructive pulmonary disease

Elnemr, Rehab; Sweed, R.; Shafiek, Hanaa

doi:10.1371/journal.pone.0217886

Cited by 4 publications

(3 citation statements)

References 37 publications

(50 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Elnemr, [27] and Eryuksel et al [28] reported that the measurement of the diaphragm thickening rate by ultrasound can accurately and quickly evaluate the diaphragm function. Brown et al [29] found that the mitochondrial density of type I muscle fibers in the diaphragm was higher than that of type II muscle fibers.…”

Section: Discussionmentioning

confidence: 99%

Shear wave elastography of the diaphragm in acute exacerbation of chronic obstructive pulmonary disease: A prospective observational study

Zhang¹,

Zhang

Yan³

et al. 2023

Medicine

View full text Add to dashboard Cite

Patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) are prone to diaphragmatic dysfunction. However, dynamic assessment of diaphragmatic function is complex and difficult, and whether the assessment of diaphragmatic function can reflect clinical indicators such as lung function in AECOPD patients remains unclear. We studied diaphragm stiffness and diaphragm stiffening rate (DSR) in AECOPD patients with acute exacerbations ≥ 2 times within 1 year and their correlation with clinical data, the diaphragmatic thickening fraction (DTF), lung function, and blood gas values. In total, 112 AECOPD patients in group C and Group D who had acute exacerbations ≥ 2 times within 1 year in the Global Initiative for Chronic Obstructive Lung Disease Guideline A (low risk, few symptoms), B (low risk, many symptoms), C (High risk, few symptoms), D (High risk, many symptoms) grouping system were included in the study. Their general clinical data, chronic obstructive pulmonary disease assessment test (CAT), modified medical research council (mMRC), number of acute exacerbations in 1 year, DTF, lung function, and blood gas analysis were collected. The diaphragm shear wave elasticity at functional residual capacity (DsweFRC) and DSR were measured by ultrasound. The DsweFRC and DSR of Group D were higher than those of Group C (P < .05). DsweFRC, DSR were negatively correlated with DTF, forced expiratory volume in 1 second (FEV1), forced vital capacity (FVC) and FEV1/FVC (r ranged from −0.293 to −0.697, all P < .05), and positively correlated with CAT score, mMRC score, and arterial carbon dioxide pressure (r ranged from 0.274 to 0.462, all P < .05) in both groups; the correlation coefficients of DsweFRC, DSR and DTF, FEV1/FVC in group D were greater than those in group C. There was no correlation between DsweFRC, DSR and arterial oxygen partial pressure in both groups (P > .05). The DsweFRC, DSR increased with the number of acute exacerbations per year in both groups. We found that diaphragmatic stiffness in AECOPD patients increased with the number of acute exacerbations within 1 year, correlated with DTF, CAT, mMRC, lung function, and arterial carbon dioxide pressure and provides a simple and practical method for dynamically assessing diaphragmatic function and disease severity in AECOPD patients.

show abstract

Section: Discussionmentioning

confidence: 99%

Shear wave elastography of the diaphragm in acute exacerbation of chronic obstructive pulmonary disease: A prospective observational study

Zhang¹,

Zhang

Yan³

et al. 2023

Medicine

View full text Add to dashboard Cite

show abstract

“…3,44,48 The phrenic nerve undergoes myelin damage, with a slowing of the conduction velocity, with higher neuropathy values for subjects with hyperinflation and, in particular, for the left phrenic area. 48,49 Neuropathic adaptations correlate positively with FEV1. 49 Such neuropathy is a direct indicator of the risk of accidental falls.…”

Section: Effect Of Dynamic Hyperinflationmentioning

confidence: 99%

“…48,49 Neuropathic adaptations correlate positively with FEV1. 49 Such neuropathy is a direct indicator of the risk of accidental falls. 50…”

Section: Effect Of Dynamic Hyperinflationmentioning

confidence: 99%

The Importance of the Diaphragm in Neuromotor Function in the Patient with Chronic Obstructive Pulmonary Disease

Bordoni¹,

Escher²,

Compalati³

et al. 2023

COPD

View full text Add to dashboard Cite

Chronic obstructive pulmonary disease (COPD) is a constant and chronic narrowing of the respiratory airways, with numerous associated symptoms, not always related to the pathological adaptation of the lungs. Statistical projections show that COPD could become the third leading cause of death globally by 2030, with a significant increase in deaths by 2060. Skeletal muscle dysfunction, including the diaphragm, is one of the causes linked to the increase in mortality and hospitalization. Little emphasis is given by the scientific literature to the importance of the diaphragm towards functional neuromotor pathological expressions. The article reviews the adaptation of the skeletal muscles, with greater attention to the adaptations of the diaphragm, thereby highlighting the non-physiological variations that the main respiratory muscle undergoes and the neuromotor impairment found in COPD. The text could be an important reflection from a clinical and rehabilitation point of view, to direct greater attention to the function and adaptation of the diaphragm muscle.

show abstract

Position effect of trans-spinal magnetic stimulation on diaphragmatic motor evoked potential in healthy humans

Ren

Liou

Vinit

et al. 2022

Journal of Applied Physiology

View full text Add to dashboard Cite

The present study was designed to evaluate the rostro-caudal and lateral-midline effects of trans-spinal magnetic stimulation on diaphragmatic motor evoked potential by utilizing a figure-of-eight coil. The bilateral diaphragm electromyograms were recorded during trans-spinal magnetic stimulation from 60-100% of maximum output in twenty-one healthy subjects. The rostro-caudal effect of trans-spinal magnetic stimulation was evaluated by comparing diaphragmatic motor evoked potential when the coil was placed at the midline of the fifth (C5) and seventh (C7) cervical vertebrae and the second thoracic vertebra (T2). The diaphragmatic motor evoked potential was also examined during midline and lateral (± 15 mm) trans-spinal magnetic stimulation to examine the lateral-midline effect. The results demonstrated that the amplitude of diaphragmatic motor evoked potential was not significantly different in response to C5, C7, or T2 trans-spinal magnetic stimulation. In addition, the sensitivity of the left and right diaphragms to trans-spinal magnetic stimulation was different, as reflected by a greater amplitude of the right diaphragmatic motor evoked potential during midline trans-spinal magnetic stimulation. Moreover, while midline trans-spinal magnetic stimulation could induce co-activation of the bilateral diaphragm, lateral trans-spinal magnetic stimulation can induce a greater motor evoked potential in the ipsilateral than the contralateral diaphragm. Finally, there was no significant sex effect on the diaphragmatic motor evoked potential induced by trans-spinal magnetic stimulation. These results suggest that trans-spinal magnetic stimulation using a figure-of-eight coil is feasible to induce diaphragmatic motor evoked potential, and there is a lateral-midline effect of trans-spinal magnetic stimulation on the bilateral diaphragm.

show abstract

Diaphragmatic motor cortex hyperexcitability in patients with chronic obstructive pulmonary disease

Cited by 4 publications

References 37 publications

Shear wave elastography of the diaphragm in acute exacerbation of chronic obstructive pulmonary disease: A prospective observational study

Shear wave elastography of the diaphragm in acute exacerbation of chronic obstructive pulmonary disease: A prospective observational study

The Importance of the Diaphragm in Neuromotor Function in the Patient with Chronic Obstructive Pulmonary Disease

Position effect of trans-spinal magnetic stimulation on diaphragmatic motor evoked potential in healthy humans

Contact Info

Product

Resources

About