Diaqua(5-carboxybenzene-1,3-dicarboxylato-κO¹)[8-ethyl-5-oxo-2-(piperazin-4-ium-1-yl)-5,8-dihydropyrido[2,3-d]pyrimidine-6-carboxylato-κ²O⁵,O⁶]zinc monohydrate

Abstract

In the title compound, [Zn(C14H17N5O3)(C9H4O6)(H2O)2]·H2O, the complex mol­ecule exists in a zwitterionic form. The ZnII ion exhibits a distorted tetra­gonal-pyramidal geometry, being coordinated by two O atoms from the zwitterionic 8-ethyl-5-oxo-2-(piperazin-4-ium-1-yl)-5,8-dihydro­pyrido[2,3-d]pyrimidine-6-carboxyl­ate (L) ligand, one O atom from the 5-carb­oxy­benzene-1,3-dicarboxyl­ate dianion, [Hbtc]2−, and two O atoms from two aqua ligands. In the crystal, N—H⋯O and O—H⋯O hydrogen bonds link the components into a three-dimensional structure. The crystal packing exhibits π–π inter­actions between the aromatic rings, with centroid–centroid distances in the range 3.466 (3)–3.667 (3) Å.

From pipemidic acid molecular salts to metal complexes and BioMOFs using mechanochemistry

“…Based on our results and a thorough search in the Cambridge Structural Database (CSD), 40,41 we were able to identify two PA polymorphic forms, 42 two polymorphs of the trihydrate derivative 43,44 and two salts, pipemidic acid hydrochloride 45 and pipemidic acid:1,2,4,5-benzenetetracarboxylic acid. 46 Also several metal complexes and metal–organic frameworks, 47,48 enclosing cadmium, 49 nickel, 50 silver, 51,52 zinc, 53–56 manganese, 54,57 cobalt 54 and copper 58–61 were reported.…”

Bioactivity of Isostructural Hydrogen Bonding Frameworks Built from Pipemidic Acid Metal Complexes

“…So far, several metal complexes with pipemidic acid have been reported [23,24]. Some enclose metal centres of cadmium [25], nickel [26], silver [27,28], zinc [29][30][31][32], manganese [30,33], cobalt [30] and copper [34][35][36][37]. However, to the best of our knowledge, few studies reporting their antimicrobial activity have been disclosed.…”