2023
DOI: 10.1002/slct.202301203
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Diarylether‐Amino Acid Conjugates as New Class of Anticancer Agents

Abstract: Diarylether (DE) is a privileged structure found in both natural products and synthetic compounds including small molecule drugs. We present the synthesis of a series of 13 new DE‐amino acid conjugates which were screened for cancer cells antiproliferation activity. Structure‐activity relationship suggests ester and phenyl groups in DE‐Phe‐OEt 4 c are important for the activity. Compound 4 c inhibited strongly MCF‐7 3D tumor sphere formation and have favourable calculated physical chemical properties according… Show more

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