Diastereoisomeric 1-Benzyl-2,3-diphenylindanes: Stereodirected Synthesis and NMR Spectra

Abstract

The stereodirected synthesis of the four racemic diastereoisomeric 1-benzyl-2,3-diphenylindanes is presented together with 1 H and 13 C NMR data.

Tetrameric aggregate of 1,c-3-diphenyltetran-r-1-olviaanR44(8) homodromic ring

“…The molecule of the title compound, (I), contains a tetrahydronaphthalene core that is often found in a large number of natural products (Bates et al, 1997), as well as bioactive and pharmaceutically interesting substances (Wang et al 2006). We have been studying the synthesis and configurational properties of indanic and tetranilic derivatives (Aguirre et al, 1998(Aguirre et al, , 1999Alesso et al, 2002Alesso et al, , 2003Vega et al, 2006). In particular, we have been seeking alternative routes to stereoselective synthesis of tetranilic derivatives via hydrogenolysis of corresponding tetranols that can be used as intermediates in the synthesis of analogues of bioactive molecules.…”

trans-2-Benzoyl-1-phenylindan

“…We have been performing extensive research on the synthesis and configurational effects of substitution in the fivemembered ring of indan derivatives (Aguirre et al, 1998;Aguirre et al, 1999;Alesso et al, 2002;Alesso et al, 2003). In particular, we have been seeking alternative routes through stereoselective synthesis for indan and tetranilic derivatives via condensation of aryl ketones.…”