Abstract:In this paper, a new diastereomerically pure isoxazolines were efficiently prepared from (S)-verbenone, the procedure involves a regioselective and a diastereoselective 1,3-dipolar cycloaddition of nitrile oxides on the monoterpene's enone. The structures of the newly obtained cycloadducts were confirmed by analytical and spectral studies (HRMS, 1 H NMR, and 13 C NMR). The relative stereochemistry of isoxazoline compounds 3a, 3c, and 3d were confirmed by xray single crystal analysis. Hirshfeld surface analysis… Show more
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