Diastereomers of Cyclopropa[a]pyrrolizine Spiro-fused with a Benzo[4,5]imidazo[1,2-a]indole Fragment: Structure Determinations Using NMR Methods

Pronina, Yulia A.; Stepakov, Alexander V.; Popova, Ekaterina A.; Boitsov, Vitali M.; Baichurin, Ruslan I.; Selivanov, Stanislav I.

doi:10.1007/s00723-023-01608-w

Appl Magn Reson

2023

DOI: 10.1007/s00723-023-01608-w

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Diastereomers of Cyclopropa[a]pyrrolizine Spiro-fused with a Benzo[4,5]imidazo[1,2-a]indole Fragment: Structure Determinations Using NMR Methods

Yulia A. Pronina,

Alexander V. Stepakov,

Ekaterina A. Popova

et al.

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Cited by 5 publications

References 30 publications

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Conformational analysis of arbidol in supercritical carbon Dioxide: Insights into 'opened' and 'closed' conformer groups

Belov,

Dyshin,

Khodov

2024

Journal of Molecular Liquids

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Conformational analysis of arbidol in supercritical carbon Dioxide: Insights into 'opened' and 'closed' conformer groups

Belov,

Dyshin,

Khodov

2024

Journal of Molecular Liquids

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Structural and sorption characteristics of an aerogel composite material loaded with flufenamic acid: insights from MAS NMR and high-pressure NOESY studies

Sobornova,

Mulloyarova,

Belov

et al. 2024

Phys. Chem. Chem. Phys.

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Conformational Analysis of 1,5-Diaryl-3-Oxo-1,4-Pentadiene Derivatives: A Nuclear Overhauser Effect Spectroscopy Investigation

Belov,

Brel,

Sobornova

et al. 2023

IJMS

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1,5-Diaryl-3-Oxo-1,4-Pentadiene derivatives are intriguing organic compounds with a unique structure featuring a pentadiene core, aryl groups, and a ketone group. This study investigates the influence of fluorine atoms on the conformational features of these derivatives in deuterated chloroform (CDCl3) solution. Through nuclear magnetic resonance (NMR) spectroscopy and quantum chemical calculations, we discerned variations in interatomic distances and established predominant conformer proportions. The findings suggest that the non-fluorinated entity exhibits a uniform distribution across various conformer groups. The introduction of a fluorine atom induces substantial alterations, resulting in the predominance of a specific conformer group. This structural insight may hold the key to their diverse anticancer activities, previously reported in the literature.

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Diastereomers of Cyclopropa[a]pyrrolizine Spiro-fused with a Benzo[4,5]imidazo[1,2-a]indole Fragment: Structure Determinations Using NMR Methods

Cited by 5 publications

References 30 publications

Conformational analysis of arbidol in supercritical carbon Dioxide: Insights into 'opened' and 'closed' conformer groups

Conformational analysis of arbidol in supercritical carbon Dioxide: Insights into 'opened' and 'closed' conformer groups

Structural and sorption characteristics of an aerogel composite material loaded with flufenamic acid: insights from MAS NMR and high-pressure NOESY studies

Conformational Analysis of 1,5-Diaryl-3-Oxo-1,4-Pentadiene Derivatives: A Nuclear Overhauser Effect Spectroscopy Investigation

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