2010
DOI: 10.1016/j.tet.2010.06.015
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Diastereoselective synthesis of 1-alkyl-2,4,6-trioxoperhydropyrimidine-5-spiro-3′-(1′,2′,3′,4′-tetrahydroquinolines)

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Cited by 13 publications
(16 citation statements)
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“…Further recent examples of type 2 tert ‐amino effect, including syntheses of pyrazolinoquinolizines and 1,4‐oxazinopyrazolines, 1,2‐fused 5 H ‐chromeno[4,3‐ b ]pyridin‐5‐ones and 6 H ‐benzo[ h ][1,6]naphthyridin‐5‐ones, naphthalenes, α‐carbolines, and spirocyclic 1,2,3,4‐tetrahydroquinolines, also demonstrate the versatility of such reactions.…”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation
“…Further recent examples of type 2 tert ‐amino effect, including syntheses of pyrazolinoquinolizines and 1,4‐oxazinopyrazolines, 1,2‐fused 5 H ‐chromeno[4,3‐ b ]pyridin‐5‐ones and 6 H ‐benzo[ h ][1,6]naphthyridin‐5‐ones, naphthalenes, α‐carbolines, and spirocyclic 1,2,3,4‐tetrahydroquinolines, also demonstrate the versatility of such reactions.…”
Section: Introductionmentioning
confidence: 99%
“…To overcome the limitation of harsh conditions led us to apply microwave-assisted chemistry; in fact, our efforts have not only led to improved yields but also opened new ways to the syntheses of otherwise hardly accessible polycyclic ring systems. [8,9] Further recent examples of type 2 tert-amino effect, including syntheses of pyrazolinoquinolizines and 1,4-oxazinopyrazolines, [10] 1,2-fused 5H-chromeno [4,3-b]pyridin-5-ones and 6H-benzo[h] [1,6] naphthyridin-5-ones, [11] naphthalenes, [12] a-carbolines, [13] and spirocyclic 1,2,3,4-tetrahydroquinolines, [14] also demonstrate the versatility of such reactions.…”
Section: Introductionmentioning
confidence: 99%
“…The reaction proceeded similarly in the case of thiobarbituric acid [35][36][37]. The authors also demonstrated that condensation under mild conditions (aqueous ethanol, 50°C, 5 min [37]) allowed to isolate the intermediate vinyl derivatives 39 with yields up to 86%.…”
Section: -97%mentioning
confidence: 84%
“…It is known that ortho-dialkylaminoarylidene derivatives of 1,3-dicarbonyl compounds, in particular, 5-arylidene barbituric acids (1), undergo a cyclization into the respective spirocyclic systems (2) 8,15,16 (Scheme 3). The rate of the Т-reaction for substrates similar to (1) is surprisingly high, the reaction proceeds much more readily than for derivatives of acyclic 1,3-dicarbonyl compounds.…”
Section: Resultsmentioning
confidence: 99%