Diastolic dysfunction and increased serum homocysteine concentrations may contribute to increased cardiovascular risk in patients with polycystic ovary syndrome

Yaralı́, Hakan; Yı́ldı́rı́r, Aylin; Aybar, F.; Kabakçı, Giray; Bükülmez, Orhan; Akgül, Ebru; Oto, Ali̇

doi:10.1016/s0015-0282(01)01937-9

Cited by 168 publications

(107 citation statements)

References 30 publications

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“…Laivuori et al [18] suggested that there was relation between insulin resistance and elevated Hcy in pregnant women with pre-eclampsia. Yarali et al [19] showed that Hcy was significantly elevated in PCOS patients as related to insulin resistance. On the other hand, Sills et al [20] did not determine any association between plasma Hcy and insulin levels in women with PCOS.…”

Section: Discussionmentioning

confidence: 99%

Relationship between Homocysteine and Insulin Resistance in Women with Polycystic Ovary Syndrome

2004

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Abstract. Hyperhomocysteinemia is a risk factor for atherosclerotic vascular diseases. It is known that plasma homocysteine levels are higher in polycystic ovary syndrome (PCOS) patients than in healthy subjects. The aim of our study was to determine the relationship between plasma homocysteine level and insulin resistance in women with PCOS. Twenty-nine patients (age, 23.90 ± 5.86 years) and twenty-five healthy subjects (age, 25.24 ± 4.28 years) were involved in the study. Plasma levels of fasting insulin, glucose, homocysteine, FSH, and LH levels were measured. A statistically significant difference in plasma concentrations of HOMA index, homocysteine, basal insulin levels and LH/FSH ratios was observed between groups (P = 0.001, P = 0.001, P = 0.001, and P = 0.01, respectively). There was no relationship between Hcy and the other variables. In multiple logistic regression analysis, age, BMI and insulin resistance were not predictors of Hcy.

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Section: Discussionmentioning

confidence: 99%

Relationship between Homocysteine and Insulin Resistance in Women with Polycystic Ovary Syndrome

2004

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“…Infatti, diverse evidenze mostrano una relazione tra malattia cardiaca e PCOS e rischio CV, cioè dislipidemia [49], insulino-resistenza (50), LVM (massa ventricolare sinistra) aumentata [51] e disfunzione diastolica del ventricolo sinistro [51,19].…”

Section: Struttura E Funzione Cardiaca Nella Pcosunclassified

“…Infatti nella PCOS è stata dimostrata disfunzione endoteliale [18) e diastolica [19] ed è stata associata sia ad elevati livelli di androgeni che ad insulino-resistenza.…”

Section: Introduzioneunclassified

The polycystic ovary syndrome: an example of obesity-related cardiovascular complication affecting young women

Orio

Cascella

Giallauria

et al. 2016

Monaldi Arch Chest Dis

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RASSEGNA IntroduzioneLa sindrome dell'ovaio policistico (PCOS) è una tra le più comuni patologie endocrine delle donne, essendone affetto il 5-10% delle donne in età riproduttiva [1,2].La PCOS è diagnosticata in presenza di due tra i tre criteri seguenti: 1. ovaie policistiche all'ecografia pelvica 2. oligo-anovulazione 3. evidenza clinica o biochimica di iperandrogenismo (Rottherdam ESHRE-ASRM 2003) [3]. La PCOS non è solo una delle cause principali di infertilità nelle donne, ma è considerata anche una vera e propria sindrome plurimetabolica [2,4,5]: obesità [6], insulino-resistenza [7], dislipidemia [8], alterazione del sistema fibrinolitico [9], sono le conseguenze metaboliche spesso evidenti in questa sindrome.Inoltre, la PCOS è associata a rischi per la salute a lungo termine, inclusi il diabete mellito [10] e la CDV (Malattia Cardiovascolare) [11][12][13][14][15].In particolare l'insulino-resistenza, l'iperandrogenismo e la dislipidemia sono probabilmente tra i maggiori fattori di rischio per l'incidenza della CDV nella PCOS. Tali fattori di rischio cardiovascolare sono spesso evidenti in giovane età, suggerendo che le donne con PCOS, rappresentano un numeroso gruppo di donne in cui è aumentato il rischio di sviluppo precoce di CDV, anche se ciò non è attualmente dimostrato [16].È stato riportato che il rischio di malattia coronarica e di infarto del miocardio è aumentato in pazienti con PCOS rispetto a donne con cicli regolari [11], anche se la mortalità dovuta a malattia circolatoria non sembra essere incrementata [17].Recenti studi hanno dimostrato un incremento della prevalenza di CDV in donne con PCOS [14][15][16][17]. Infatti nella PCOS è stata dimostrata disfunzione endoteliale [18) e diastolica [19] ed è stata associata sia ad elevati livelli di androgeni che ad insulino-resistenza.Di recente, insieme ai classici fattori di rischio CV, come i livelli di colesterolo totale e i livelli di lipoproteine ad alta densità per il colesterolo (HDL-C), l'obesità, l'omocisteina e l'ipertrofia ventricolare sinistra si sono dimostrati essere associati, indipendentemente, ad un incremento del rischio CV [20].

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“…Increased free testosterone is consistently associated with increased systolic and diastolic blood pressures [151][152][153][154][155][156][157][158]. Animal studies indicate the prohypertensive effect of androgens are mediated through increased vascular tone via upregulation of thromboxane A2 expression, norepinephrine, angiotensin II and endothelin-1 synthesis [159] : androgens may also influence blood pressure by affecting the reninangiotensin-aldosterone system [159].…”

Section: Paper Imentioning

confidence: 99%

“…Thus, it is plausible studies indicating no difference in PAI-1 activity have included a more heterogeneous population of PCOS patients with regard to hyperandrogenism. For example, Atiomo et al [102] do not assess biochemical hyperandrogenism and, in two studies [103,159], only high testosterone is used for the assessment of hyperandrogenism. One prior study [100] uses increased FAI as the hyperandrogenism criterion in PCOS patients, while adjusting for BMI, and report increased PAI-1 activity in the PCOS group: this finding is in accordance with the findings of this study.…”

mentioning

confidence: 99%

Metabolic Aspects of Polycystic Ovary Syndrome

2015

Postgraduate Obstetrics & Gynecology

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Diastolic dysfunction and increased serum homocysteine concentrations may contribute to increased cardiovascular risk in patients with polycystic ovary syndrome

Cited by 168 publications

References 30 publications

Relationship between Homocysteine and Insulin Resistance in Women with Polycystic Ovary Syndrome

Relationship between Homocysteine and Insulin Resistance in Women with Polycystic Ovary Syndrome

The polycystic ovary syndrome: an example of obesity-related cardiovascular complication affecting young women

Metabolic Aspects of Polycystic Ovary Syndrome

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