Diastolic Dysfunction in Rheumatoid Arthritis: A Meta‐Analysis and Systematic Review

Aslam, Fawad; Bandeali, Salman; Khan, Nasim A.; Alam, Mahboob

doi:10.1002/acr.21861

Cited by 92 publications

(89 citation statements)

References 59 publications

(56 reference statements)

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“…In both studies, RA patients were compared with healthy subjects, and none of the patients or control subjects had any associated comorbidities to verify the effect of the disease on the heart. Three successive systematic reviews with meta-analyses corroborated the above-described findings (4)(5)(6). The first meta-analysis used pooled data from 10 controlled studies and confirmed valvular and pericardial involvement in RA (4), the second confirmed the increased prevalence of left ventricular diastolic dysfunction in patients with RA (5), and the third highlighted the detrimental effect of RA on left ventricular mass (6).…”

supporting

confidence: 53%

Cardiovascular Events in Rheumatoid Arthritis—Time to See Beyond Articular Involvement in “Real World” Clinical Practice: Comment on the Article by Mackey et al

Corrao

Messina

Allotta

et al. 2016

Arthritis & Rheumatology

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supporting

confidence: 53%

Cardiovascular Events in Rheumatoid Arthritis—Time to See Beyond Articular Involvement in “Real World” Clinical Practice: Comment on the Article by Mackey et al

Corrao

Messina

Allotta

et al. 2016

Arthritis & Rheumatology

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“…In our studies, although the higher LVMI noted in the RA patients with high-ACPA levels fell within the normal range, a progressive increase in LVM is a heart failure precursor in the general population, and strong sudden cardiac death predictor, even in subsets with normal ejection fraction [13,14]. A recent meta-analysis of cross-sectional studies in RA patients without clinical heart failure revealed no consensus on LVMI differences between RA and controls, as higher LVMIs, lower LVMIs and no difference in LVMI have all been reported [10,15]. This could be due to variability in time of assessment along the continuum of the RA disease process.…”

Section: Discussionmentioning

confidence: 99%

Association of anti-citrullinated protein or peptide antibodies with left ventricular structure and function in rheumatoid arthritis

et al. 2016

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Objective. High levels of ACPAs in RA are associated with more severe arthritis and worse prognosis. However, the role of ACPAs in mediating the increased risk of heart failure in RA remains undefined. We examined whether specific ACPAs were associated with subclinical left ventricular (LV) phenotypes that presage heart failure.Methods. Sera from RA patients without clinical cardiovascular disease were assayed for specific ACPAs using a custom Bio-Plex bead assay, and their cross-sectional associations with cardiac magnetic resonance-derived LV measures were evaluated. High ACPA level was defined as 5 75th percentile. Findings were assessed in a second independent RA cohort with an expanded panel of ACPAs and LV measures assessed by 3D-echocardiography.Results. In cohort 1 (n = 76), higher levels of anti-citrullinated fibrinogen 41 60 and anti-citrullinated vimentin antibodies were associated with a 10 and 6% higher adjusted mean LV mass index (LVMI), respectively, compared with lower antibody levels (P < 0.05). In contrast, higher levels of anticitrullinated biglycan 247 266 were associated with a 13% lower adjusted mean LVMI compared with lower levels (P < 0.001). In cohort 2 (n = 74), the association between ACPAs targeting citrullinated fibrinogen and citrullinated vimentin peptides or protein and LVMI was confirmed: higher anticitrullinated fibrinogen 556 575 and anti-citrullinated vimentin 58 77 antibody levels were associated with a higher adjusted mean LVMI (19 and 15%, respectively; P < 0.05), but no association with biglycan was found.Conclusion. Higher levels of antibodies targeting citrullinated fibrinogen and vimentin peptides or protein were associated with a higher mean LVMI in both RA cohorts, potentially implicating autoimmune targeting of citrullinated proteins in myocardial remodelling in RA.Key words: anti-citrullinated peptide antibody (ACPA), RA, ventricular mass, CVD Rheumatology key messages. Higher levels of ACPAs targeting citrullinated fibrinogen and citrullinated vimentin peptides or protein were associated with higher left ventricular mass index. . Seroreactivity towards citrullinated proteins may play a role in myocardial remodelling in RA.

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“…In the literature, diastolic dysfunction has been studied in some other rheumatic diseases such as rheumatoid arthritis, scleroderma, ankylosing spondylitis, and Behçet's disease. [14][15][16][17][18] These studies focused on inflammatory mechanisms, vasculitic and fibrotic changes of the heart which are the causes of distensibility, abnormal diastolic filling, impaired relaxation, and diastolic stiffness of the left ventricle. However, FM is a non-inflammatory disorder different from the aforementioned rheumatic diseases.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Ventricular Diastolic Function in Patients With Fibromyalgia Syndrome

Sayılır

Ergün

Ekiz³

2018

Arch Rheumatol

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Objectives:This study aims to compare the diastolic functions between fibromyalgia (FM) patients and control subjects by using transthoracic echocardiography. Patients and methods:This case-control and cross-sectional study included 34 female FM patients (mean age 43.6±8.2 years; range 28 to 57 years), who were diagnosed by The American College of Rheumatology 1990 Criteria for the Classification of Fibromyalgia and defined as the FM group. A control group was defined consisting of 30 healthy females (mean age 41.2±9.1 years; range 22 to 54 years). Echocardiography findings of the groups were compared. Results: The body mass index and mean disease duration of the FM group were 25.37±2.71 kg/m 2 and 12.24 months, respectively. The body mass index of the control group was 25.58±1.49 kg/m 2 . There was no significant difference between the groups in terms of age and body mass index. Isovolumetric relaxation time and mitral E-wave deceleration time values were significantly higher in the FM group than in the control group (p=0.047, p=0.003, respectively). Conclusion: Isovolumetric relaxation time and mitral valve deceleration time are significantly prolonged in FM patients compared with healthy subjects. Female patients with FM seem to be under risk of impaired relaxation and diastolic function of the left ventricle.

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Diastolic Dysfunction in Rheumatoid Arthritis: A Meta‐Analysis and Systematic Review

Cited by 92 publications

References 59 publications

Cardiovascular Events in Rheumatoid Arthritis—Time to See Beyond Articular Involvement in “Real World” Clinical Practice: Comment on the Article by Mackey et al

Cardiovascular Events in Rheumatoid Arthritis—Time to See Beyond Articular Involvement in “Real World” Clinical Practice: Comment on the Article by Mackey et al

Association of anti-citrullinated protein or peptide antibodies with left ventricular structure and function in rheumatoid arthritis

Evaluation of Ventricular Diastolic Function in Patients With Fibromyalgia Syndrome

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