Diatom Cells Grown and Baked on a Functionalized Mica Surface

Umemura, Kazuo; Noguchi, Yusuke; Ichinose, Takuya; Hirose, Yo; Kuroda, Reiko; Mayama, Shigeki

doi:10.1007/s10867-008-9086-z

Cited by 29 publications

(16 citation statements)

References 19 publications

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“…In order to analyze by optical or electron microscopy the morphology of their surface, organic matter must be removed by proper cleaning protocol. High temperatures, i.e., baking rough material at 400–800 °C can be used; the procedure, generally used in industrial applications, has the disadvantage that can close the micropores and damage the original architecture of frustules . An alternative approach is a mixture of different acids.…”

Section: Bioderived Nanostructured Silicamentioning

confidence: 99%

Synthetic vs Natural: Diatoms Bioderived Porous Materials for the Next Generation of Healthcare Nanodevices

Rea¹,

Terracciano²,

Stefano³

2016

Adv Healthcare Materials

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Nanostructured porous materials promise a next generation of innovative devices for healthcare and biomedical applications. The fabrication of such materials generally requires complex synthesis procedures, not always available in laboratories or sustainable in industries, and has adverse environmental impact. Nanosized porous materials can also be obtained from natural resources, which are an attractive alternative approach to man-made fabrication. Biogenic nanoporous silica from diatoms, and diatomaceous earths, constitutes largely available, low-cost reservoir of mesoporous nanodevices that can be engineered for theranostic applications, ranging from subcellular imaging to drug delivery. In this progress report, main experiences on nature-derived nanoparticles with healthcare and biomedical functionalities are reviewed and critically analyzed in search of a new collection of biocompatible porous nanomaterials.

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Section: Bioderived Nanostructured Silicamentioning

confidence: 99%

Synthetic vs Natural: Diatoms Bioderived Porous Materials for the Next Generation of Healthcare Nanodevices

Rea¹,

Terracciano²,

Stefano³

2016

Adv Healthcare Materials

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“…Losic et al [8] tested the hardness and elastic modulus of two types of frustules using atomic force microscopy (AFM) and found that the cribellum, cribrum and girdles have different mechanical properties, and the elastic modulus of frustule is similar to that of porous silicon manufactured by anodic oxidation. Umemura et al [38] found that the structure and pores deform after heating at 800°C for 2 h. The frustule reacts with hydrofluoric acid and strong alkali [39,40], and thus it is compatible with silicon processing technology, such as wet etching, LIGA micromachining and silicon bonding [41,42].…”

Section: Materials Properties Of Diatom Frustulesmentioning

confidence: 99%

“…Compared with baking [38] and alkali etching, HF etching is a faster and cleaner method for pore enlargement and structure modification. (ii) Structural modification based on the natural methods of frustule formation: the formation of frustules in diatom cells is a bottom-up process.…”

Section: Structural Modification Of Diatom Frustulementioning

confidence: 99%

“…Several studies have reported success in modifying the surface of diatoms and substrates so as to encourage bonding with covalent bonds. Umemura et al [38] used 3-Aminopropyltriethoxysilane (APES) to modify the mica substrate, and then the cells of pennate diatom would then readily attach to the modified surface during culturing. Wang et al [91] used polyethylene with various electrical properties to separately modify the frustules and the substrate, and then the frustules can assemble and bind onto the area of the substrate having inverse electric charges.…”

Section: Bonding Technology For Diatom Frustulesmentioning

confidence: 99%

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Bio-manufacturing technology based on diatom micro- and nanostructure

et al. 2012

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Diatom frustules, considered as novel bio-functional materials, display a diversity of patterns and unique micro-and nanostructures which may be useful in many areas of application. Existing devices directly use the original structure of the biosilica frustules, limiting their function and structural scale. Current research into the shapes, materials and structural properties of frustules are considered; a series of frustule processing methods including structure processing, material modification, bonding and assembly techniques are reviewed and discussed. The aim is to improve the function of diatom frustules allowing them to meet the design requirements of different types of micro devices. In addition, the importance of the comprehensive use of diatom processing methods in device research is discussed using biosensors and solar cells as examples, and the potential of bio-manufacturing technology based on diatom frustules is examined. Nature presents a wide range of functional structures. Particularly at the micro-and nanoscale, the complexity and functionality of biological structures are far greater than those of equivalent artificial devices, making these biological structures an appropriate subject for biotechnology and bio-manufacturing [1,2]. In our previous studies, we have reported bio-limited forming [3] and bio-replication forming [4,5] methods for manufacturing functional particles or surface morphology from biological structures. Micro devices with highly desirable structure and characteristics could be produced from biological micro-or nanostructures. Single-celled diatoms are widely distributed in rivers, lakes and other water bodies, and have a fast (exponential) reproductive rate. The cell wall of a diatom known as the frustule, has a transparent structure composed of amorphous silica [6]. The frustule has good mechanical strength [7,8], a variety of three-dimensional (3D) shapes [9,10], multi-level nanopores and microstructures [11,12], large surface area and unique optical properties [13][14][15], making it a potential novel functional material for bio-manufacturing. Studies on theoretical understanding, manufacturing methods and functionalization of diatom frustules are ongoing. In the last two centuries, the importance of diatom frustules in the field of micro-and nanotechnology has become increasingly evident. The potential of frustules has been extensively explored by academics and for commercial application. The resulting new theories and techniques have found wide application, leading to the formation of a new interdisciplinary area of research called diatom-based bio-nanotechnology (or diatom nanotechnology) [16][17][18][19][20][21]. The potential for diatoms in device applications, such as high-sensitivity gas sensors [22], drug delivery devices [23], biocarriers for biosensors [24][25][26][27], micro-filters [12,28], solar cells, battery electrodes and electroluminescent display devices [19] has been examined. However, the direct

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“…Losic 等人 [7] 通过原子力显微镜(AFM)对壳体的硬度和弹性模量进行测试, 发现壳体棘孔、孔室、实心壳片区域力学性能存在差异, 弹性模量与阳极氧化制备的多孔硅材料机械性能相近 . 结构耐热性方面 , Umemura 等人 [37] 发现舟形藻壳体在 800℃加热 2 h 后结构与微孔变形. 可加工性方面, SiO 2 壳体能与强碱和氢氟酸反应, 兼容硅加工工艺, 如湿法刻蚀、LIGA 体微加工、硅键合等.…”

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