Diatrizoate Levels in the Kidney and Lymph Nodes in Acute Renal Failure in the Rat

McLachlan, M. S. F.; Davies, Robert L.; Leach, K. G.

doi:10.1159/000180423

Cited by 3 publications

(3 citation statements)

References 22 publications

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“…The 30% increase in renal size in ARF in rats [17], which resembles that seen in man [2], cannot account for the large differences in concentration of diatrizoate between the ARF and control groups even at the highest dose where the difference is least. We find renal iodine content in ARF to be directly proportional to the injected dose of contrast medium.…”

Section: Discussionmentioning

confidence: 89%

“…Observations suggesting that the density of the nephrogram in patients with ARF may be as great as that seen in healthy subjects given similar doses of contrast medium [5] imply that any alteration in glomerular filtration is minimal. However, previous experiments in rats with glycerol-induced ARF given small doses of diatrizoate [17] showed renal concentrations of diatrizoate to be only one fifth of those in controls. The present work, extending these experiments, assesses the effect of dose on concentration and distribution of diatrizoate in the rat kidney.…”

Section: Introductionmentioning

confidence: 85%

“…Obstruction in the distal segments of proximal tubules [16,21], would tend to increase intrarenal accumulation of contrast medium in ARF. Intrarenal obstruction may ac count for opacification of an outer rim of renal tissue after very high intravenous doses in ARF in the rat [16] and for a nephrogram of increasing density seen in some patients in ARF during high dose intravenous urography [12,25], Persistence of the nephrogram in ARF may be largely explained by delayed clearance of contrast medium from plasma [17]. Quantitative assess-merit of radiographic density is difficult, however, being essentially subjective.…”

Section: Discussionmentioning

confidence: 99%

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Effect of Dose on Renal Diatrizoate Concentrations in Experimental Acute Renal Failure

Robinson¹,

Gaunt²,

McLachlan³

1976

Nephron

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In rats with glycerol-induced acute renal failure (ARF) and controls, renal concentrations of ¹²⁵I-labelled sodium diatrizoate were measured 5 min after intravenous doses ranging from 14 to 1,800 mg/kg body weight. Renal concentrations of diatrizoate, at all doses, were much higher in controls than in ARF. A linear relationship existed between dose and renal concentration in ARF. In controls, at doses above 225 mg/kg body weight, the fraction of the dose present in the kidneys diminished and renal iodine content approached that observed in ARF. Differences in diatrizoate concentration which existed between cortical and medullary zones in healthy kidneys at low doses were progressively eliminated as dosage increased, consistent with the osmotic diuretic effect of diatrizoate. In ARF, the pattern of intrarenal distribution at all doses was similar to that seen in controls at high doses, though concentrations in outer cortex were consistently slightly higher than those in inner cortex. These observations suggest continuing, though reduced, filtration of diatrizoate in ARF by glomeruli already subjected to a large solute load.

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Section: Discussionmentioning

confidence: 89%

Section: Introductionmentioning

confidence: 85%

Section: Discussionmentioning

confidence: 99%

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Effect of Dose on Renal Diatrizoate Concentrations in Experimental Acute Renal Failure

Robinson¹,

Gaunt²,

McLachlan³

1976

Nephron

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Case 45-1984

Cabot¹,

Scully²,

Mark³

et al. 1984

N Engl J Med

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Nephrographic density and renal diatrizoate content in experimental acute renal failure

Robinson¹,

Gaunt²,

McLachlan³

1976

BJR

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Reversible acute renal failure (ARF) was induced in rats by intramuscular injection of glycerol. In these animals and controls, renal concentrations of 125I-labelled sodium diatrizoate, injected intravenously in doses similar to those used clinically, were compared with the density of the nephrogram, subjectively assessed under carefully controlled conditions. Though a good statistical correlation existed between renal diatrizoate concentration and nephrographic density, individual variation was wide. At any given level of renal iodine concentration, nephrograms were judged to be denser in ARF than in controls. This was not due to differences in whole-body opacification or renal size, but was partly explained by the greater visibility of renal outlines on plain films in ARF. However, though at all doses of diatrizoate renal iodine concentrations were higher in controls, differences in nephrographic density were in general difficult to detect.

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Diatrizoate Levels in the Kidney and Lymph Nodes in Acute Renal Failure in the Rat

Cited by 3 publications

References 22 publications

Effect of Dose on Renal Diatrizoate Concentrations in Experimental Acute Renal Failure

Effect of Dose on Renal Diatrizoate Concentrations in Experimental Acute Renal Failure

Case 45-1984

Nephrographic density and renal diatrizoate content in experimental acute renal failure

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