2003
DOI: 10.1016/s0197-0186(02)00213-9
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Diazepam and chlormethiazole attenuate the development of hyperthermia in an animal model of the serotonin syndrome

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Cited by 59 publications
(28 citation statements)
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“…Changes in body-core temperature (claudqcT cor ), attributable to 5-HT-mediated thermoregulation in the central nervous system (Lin et al, 1998), are a most obvious indication for the toxidrome (Isbister and Buckley, 2005). Several studies conducted in animals have revealed both hyperthermia and hypothermia in the toxidrome (Abdel-Fattah et al, 1995, 1997Nisijima et al, 2001Nisijima et al, , 2003. However, little is known about changes in body-core temperature in the context of different degrees of toxicity although in the severe state their relationship has been examined by others using a single dose protocol (Grahame-Smith, 1971b;Jacobs and Klemfuss, 1975;Nisijima et al, 2001).…”
Section: Introductionmentioning
confidence: 99%
“…Changes in body-core temperature (claudqcT cor ), attributable to 5-HT-mediated thermoregulation in the central nervous system (Lin et al, 1998), are a most obvious indication for the toxidrome (Isbister and Buckley, 2005). Several studies conducted in animals have revealed both hyperthermia and hypothermia in the toxidrome (Abdel-Fattah et al, 1995, 1997Nisijima et al, 2001Nisijima et al, , 2003. However, little is known about changes in body-core temperature in the context of different degrees of toxicity although in the severe state their relationship has been examined by others using a single dose protocol (Grahame-Smith, 1971b;Jacobs and Klemfuss, 1975;Nisijima et al, 2001).…”
Section: Introductionmentioning
confidence: 99%
“…It is suggested to prescribe Cyproheptadine for patients in moderate and severe cases, although there are no randomized controlled trials about severe cases (47,48). Diazepam is a GABA mimetic, which has been studied more and blunts the hyper-adrenergic symptoms of serotonin syndrome (42,49,50). Diazepam not only sedates the patient, but also improves mild hypertension and tachycardia, and reduces fever (1,51).…”
Section: Discussionmentioning
confidence: 99%
“…The avoidance of neurological effects would need to be addressed in the design and evaluation of related compounds. For example, compounds that are predicted to have neurological effects could be screened in animal models of the serotonin syndrome (24,28). These data indicate that 8-OH-DPAT may target a 5HT1A-like receptor present in P. falciparum and thus may be used to identify this membrane channel by affinity purification or as a biotinylated probe for quantitative proteomic analysis (36).…”
Section: Discussionmentioning
confidence: 99%