Diazepam and Succinylcholine-Induced Muscle Pains

Verma, R. S.; Chatterji, Sumit; Mathur, Neelu

doi:10.1213/00000539-197805000-00002

Cited by 23 publications

(3 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Of the many regimens which have been proposed as a means of reducing the incidence of myalgia [9,[14][15][16][17][18][19], the most effective and widely used method is pretreatment with a small dose of non-depolarizing neuromuscular blocker [20]. A review of the literature revealed that vecuronium was probably the best agent in this respect [4,5,7] and for this reason we chose to compare rocuronium with vecuronium.…”

Section: Discussionmentioning

confidence: 99%

Rocuronium pretreatment reduces suxamethonium-induced myalgia: comparison with vecuronium

Findlay¹,

Spittal²

1996

British Journal of Anaesthesia

View full text Add to dashboard Cite

We have studied, in 150 patients undergoing elective oral surgery, the effectiveness and sequelae of pretreatment with rocuronium for reducing myalgia after suxamethonium. Patients were allocated randomly to one of three groups: anaesthesia was induced with propofol and fentanyl, and group V received vecuronium 1 mg, group R rocuronium 6 mg and group P placebo pretreatment. Suxamethonium 1.5 mg kg-1 was given 60 s after the pretreatment agent. All patients received ketorolac 10 mg i.v. and morphine 10 mg i.m. for analgesia. The incidence of postoperative myalgia on day 1 after rocuronium (20%) was significantly less than after vecuronium (42%) (P < 0.05) or placebo (70%) (P < 0.01). By day 4 the incidence of myalgia was 28.6% in the rocuronium group, 46.3% in the vecuronium group and 95% in the placebo group. Intubating conditions were not affected adversely by any pretreatment regimen.

show abstract

Section: Discussionmentioning

confidence: 99%

Rocuronium pretreatment reduces suxamethonium-induced myalgia: comparison with vecuronium

Findlay¹,

Spittal²

1996

British Journal of Anaesthesia

View full text Add to dashboard Cite

show abstract

“…Pretreatment with diazepam inhibits the action of succinylcholine [71]. It is also postulated that the effects of diazepam on pain threshold and its amnesic effect on the timing of the perception of pain might contribute to its ability to decrease the severity of postoperative myalgia [72]. Neither diazepam nor midazolam influenced the incidence or severity of fasciculations seen with succinylcholine or the duration of the neuromuscular block [73].…”

Section: Methods Used To Reduce Myalgiamentioning

confidence: 99%

Succinylcholine‐associated postoperative myalgia

Wong

Chung

2000

Anaesthesia

View full text Add to dashboard Cite

SummaryThe subject of postoperative myalgia associated with the use of succinylcholine is reviewed. We discuss the mechanisms of succinylcholine-induced myalgia and the techniques available to prevent and treat the myalgia. In situations where patients are at risk of developing myalgia and succinylcholine is the neuromuscular blocker of choice, the use of a combination of techniques may prove to be a useful strategy.

show abstract

“…3 reported that 10 mg diazepam pretreatment reduced the incidence of muscle pain after the administration of suxarnethoniurn to 16%, while in this series the same dose of diazepam reduced the incidence to 20%. Diazepam pretreatment in 5, 15 and 20 mg doses also reduced the incidence of muscle pain thus confirming that the drug has protective action against suxamethonium muscle pains.…”

Section: Discussionmentioning

confidence: 55%

Diazepam and suxamethonium muscle pain (a dose‐response study)

Verma

1982

Anaesthesia

View full text Add to dashboard Cite

Postoperative muscle pain following suxamethonium is a well known problem.',* Recently it has been reported that diazepam has protective effects against these muscle pains3 This study was taken to confirm this observation and also to observe a dosc rclatcd cffcct of diazepam on suxamethonium pains. Muterid und method.,Various factors such as age, sex, type and duration of' operation. body weight. body position and anaesthetic technique may affect the incidence of suxaniethonium pains. In this study female patients of average body weight 40 kg. aged 20 to 45 years, of physical status 1 in the ASA classification, undergoing tuba1 ligation were studied. Patients with cardiac. respiratory. renal and neurological disorders were excluded. All patients were hospitalised and were ambulatory 6 to 8 hours after operation. Patients were given various doses of diazepam (Table I). It was planned to have 25 patients in each group, but in the diazepam group nine paticnts given a dose of 5 mg diazepam required an additional dose of suxamethonium and have. therefore. been excluded from the series.All patients werc given atropine 0.65 mg intravenously prior to induction. No other drugs were used. .,. Experimrn~al Diazepam given ~~Anaesthesia for the patients in the control group was induced with 250 mg thiopentone. The same dose was uscd in all patients becausc of the infucnce of thiopentone on the incidence of pain after administration of s u~a m e t h o n i u m .~ Suxamethonium 50 mg was given immediately after the thiopentone as a single injcction. Anaesthesia was maintained with oxygen and ether through a sem-closed circuit. Thc same tcchnique was employed in the experimental group except that diazepam in 5. 10. 15 and 20 mg doses was given intravenously 5 minutes prior t o suxamethonium.Postoperatively paticnts were asked about muscle pains by a doctor who was unaware of the drugs used

show abstract

Diazepam and Succinylcholine-Induced Muscle Pains

Cited by 23 publications

References 0 publications

Rocuronium pretreatment reduces suxamethonium-induced myalgia: comparison with vecuronium

Rocuronium pretreatment reduces suxamethonium-induced myalgia: comparison with vecuronium

Succinylcholine‐associated postoperative myalgia

Diazepam and suxamethonium muscle pain (a dose‐response study)

Contact Info

Product

Resources

About