Diazonium Gold Salts as Novel Surface Modifiers: What Have We Learned So Far?

Ahmad, Ahmad A. L.; Workie, Bizuneh; Mohamed, Ahmed A.

doi:10.3390/surfaces3020014

Cited by 8 publications

(3 citation statements)

References 50 publications

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“…In this approach, the gold anion AuCl 4 can be the counter ion of the diazonium salt, for example: [4-NO 2 -C 6 H 4 N≡N]AuCl 4 . [77] Gold nanoparticles are formed by reduction of both the diazonium salt and AuCl 4 with borabicyclo[3.3.1]nonane (9-BBN). This produces gold nanoparticles directly modified by nitrophenyl groups.…”

Section: Graphene Nanoplateletsmentioning

confidence: 99%

Surface functionalization of nanomaterials by aryl diazonium salts for biomedical sciences

Luo

Onidas

et al. 2021

Advances in Colloid and Interface Science

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Nanoparticles (NPs) can be prepared by simple reactions and methods from a number of materials. Their small size opens up a number of applications in different fields, among which biomedicine, including: i) drug delivery, ii) biosensors, iii) bioimaging, iv) antibacterial activity. To be able to perform such tasks, NPs must be modified with a variety of functional molecules, such as drugs, targeting groups, chemical tags or antibacterial agents, and must also be prevented from aggregation. The attachment must be stable to resist during the transportation to the targeted location. Diazonium salts, which have been widely used for coupling applications and surface modification, fulfil such criteria. Moreover, they are simple to prepare and can be easily substituted with a large number of organic groups. This review describes the use of these compounds in nanomedicine with a focus on the construction of nanohybrids derived from metal, oxide and carbon-based NPs as well as viruses.

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Section: Graphene Nanoplateletsmentioning

confidence: 99%

Surface functionalization of nanomaterials by aryl diazonium salts for biomedical sciences

Luo

Onidas

et al. 2021

Advances in Colloid and Interface Science

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“…However, they are often poorly soluble in water and, therefore, does not fit into the trend of green chemistry [16]. The most stable diazonium salts turned out to be the diazonium tosylates, tetrachloroaurates, and triflates [17][18][19][20][21][22]. These salts are well soluble in water, and some of them can be stored at room temperature even for several years.…”

Section: Introductionmentioning

confidence: 99%

Diazonium Modification of Inorganic and Organic Fillers for the Design of Robust Composites: A Review

Sandomierski

Voelkel

2020

J Inorg Organomet Polym

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This review focuses on fillers modified with diazonium salts and their use in composites. We reviewed scientific publications and presented information about such diazonium-modified fillers as boron nitride, carbon fillers, cellulose, clay, silica, titanium dioxide, and zeolite. The fillers were divided into two groups. The first group includes those that form covalent bonds with the polymer, while the second includes those that do not form them. This review indicates a tremendous impact of filler modification using diazonium salts on the properties of composites. The review presents examples of the impact of filler on such properties as thermal conductivity, thermal stability, and mechanical properties (e.g., interfacial shear strength, compressive strength, flexural strength). The presented review indicates the enormous potential of composites with diazonium-modified fillers in control drug release, antistatic coatings, electrode materials, photocatalysts, bone tissue engineering scaffolds, fuel cell applications, abrasive tools, and electromechanical strain sensor. We hope that this review will help both research groups and industry in choosing fillers for given types of polymers and obtaining composites with even better properties.

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“…One of the advantages of this technique is the formation of a covalent bond between an organic compound and a substrate, ensuring exceptional adhesion and long-term stability of modified surfaces 18 . Several techniques can be employed for diazonium salt-based surface modification, including immersion methods, vapor phase modification, and solution-based approaches 19 . However, electrochemical deposition stands out as a superior method due to its control over the modification process, leading to the formation of uniform layers with controlled thickness.…”

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confidence: 99%

Modulating pro-adhesive nature of metallic surfaces through a polypeptide coupling via diazonium chemistry

Patel,

Skonieczna,

Turczyn

et al. 2023

Sci Rep

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The design of biomaterials able to facilitate cell adhesion is critical in the field of tissue engineering. Precise control of surface chemistry at the material/tissue interface plays a major role in enhancing the interactions between a biomaterial and living cells. Bio-integration is particularly important in case of various electrotherapies, since a close contact between tissue and electrode's surface facilitates treatment. A promising approach towards surface biofunctionalization involves the electrografting of diazonium salts followed by the modification of organic layer with pro-adhesive polypeptides. This study focuses on the modification of platinum electrodes with a 4-nitrobenzenediazonium layer, which is then converted to the aminobenzene moiety. The electrodes are further biofunctionalized with polypeptides (polylysine and polylysine/laminin) to enhance cell adhesion. This study also explores the differences between physical and chemical coupling of selected polypeptides to modulate pro-adhesive nature of Pt electrodes with respect to human neuroblastoma SH-SY5Y cells and U87 astrocytes. Our results demonstrate the significant enhancement in cell adhesion for biofunctionalized electrodes, with more amplified adhesion noted for covalently coupled polypeptides. The implications of this research are crucial for the development of more effective and functional biomaterials, particularly biomedical electrodes, which have the potential to advance the field of bioelectronics and improve patients' outcomes.

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Diazonium Gold Salts as Novel Surface Modifiers: What Have We Learned So Far?

Cited by 8 publications

References 50 publications

Surface functionalization of nanomaterials by aryl diazonium salts for biomedical sciences

Surface functionalization of nanomaterials by aryl diazonium salts for biomedical sciences

Diazonium Modification of Inorganic and Organic Fillers for the Design of Robust Composites: A Review

Modulating pro-adhesive nature of metallic surfaces through a polypeptide coupling via diazonium chemistry

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