Dibenzazepine‐Based Sodium Channel Blockers for the Treatment of Neuropathic Pain

Nelson, Derek W.

doi:10.1002/9783527664450.ch8

Search citation statements

Order By: Relevance

Paper Sections

Select...

Introduction1

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2016

2023

Publication Types

Select...

Article3

Preprint1

Relationship

Self Cite0

Independent4

Authors

Journals

Cited by 4 publications

(1 citation statement)

References 81 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Similar to carbamazepine, the dibenzoazepine (DBA) framework is often found in pharmaceuticals and agrochemicals, and numerous methods have been developed for their synthesis. 7 Despite the abundant synthetic methods, there are only a few reports on the synthesis of 10Ar-DBAs. This framework was first synthesized by Bergmann et al via ring expansion and rearrangement using 9-(α-hydroxybenzyl)acridine.…”

Section: Introductionmentioning

confidence: 99%

A new approach to 10-arylated 5H-dibenzo[b,f]azepines using syn-selective hydrohalogenation of ethynylaniline

et al. 2022

View full text Add to dashboard Cite

show abstract

Section: Introductionmentioning

confidence: 99%

A new approach to 10-arylated 5H-dibenzo[b,f]azepines using syn-selective hydrohalogenation of ethynylaniline

et al. 2022

View full text Add to dashboard Cite

show abstract

Iodine(III)‐Mediated Oxidation of Anilines to Construct Dibenzazepines**

White

Zorigt

Deng

et al. 2023

Chemistry A European J

View full text Add to dashboard Cite

The development of an efficient process that produces bioactive medium-sized N-heterocyclic scaffolds from 2-substituted anilines using either iodosobenzene or (bis(trifluoroacetoxy)iodo)-benzene is reported. The tether between the sulfonamide and the aryl group can be varied to access dihydroacridine-, dibenzazepine-, or dibenzazocine scaffolds. While substitution on the aniline portion is limited to electron-neutral-or electron-poor groups, a broader range of functional groups are tolerated on the ortho-aryl substituent and site selective CÀ NAr bond formation can be achieved. Preliminary mechanistic investigations suggest that mediumring formation occurs via radical reactive intermediates.

show abstract