Dibenzo-α-pyrones: a new class of larvicidal metabolites against<i>Aedes aegypti</i>from the endophytic fungus<i>Hyalodendriella</i>sp. Ponipodef12

Mao, Ziling; Lai, Daowan; Liu, Xunda; Fu, Xiaoxiang; Meng, Jiajia; Wang, Ali; Wang, Xiaohan; Sun, Weibo; Liu, Zhi Long; Zhou, Ligang; Liu, Yang

doi:10.1002/ps.4481

Cited by 26 publications

(16 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The lowest MIC observed from A. pullulans was 0.17 mg/mL. Hyalodendriella sp., has been reported to contain bioactive properties that inhibit bacterial growth [28,43] and fungal growth [44]. This validates the results we obtained in this study, that fungal endophytes from plants have the potential to inhibit microorganisms other than bacteria, such as fungi.…”

Section: Discussionsupporting

confidence: 91%

Diversity and Antimicrobial Activity of Culturable Fungal Endophytes in Solanum mauritianum

Pelo

Mavumengwana

Green

2020

IJERPH

View full text Add to dashboard Cite

Plant endophytes are microbial sources of bioactive secondary metabolites, which mimic the natural compounds chemistry of their respective host plants in a similar manner. This study explored the isolation and identification of fungal endophytes, and investigated the antibacterial and antimycobacterial activity of their crude extracts. Fungal endophytes were isolated from Solanum mauritianum, identified using morphological traits and internal transcribed spacer ribosomal-deoxyribonucleic acid (ITS-rDNA) sequence analysis. Eight fungal endophytes were identified as Aureobasidium pullulans, Paracamarosporium leucadendri, Cladosporium sp., Collectotrichum boninense, Fusarium sp., Hyalodendriella sp., and Talaromyces sp., while Penicillium chrysogenum was isolated from the leaves and unripe fruits. Good activity was observed for the crude extracts of Paracamarosporium leucadendri inhibiting Mycobacterium bovis, Klebsiella pneumoniae, and Pseudomonas aeruginosa at 6 µg/mL. Crude extracts of Fusarium sp., showed activity at 9 μg/mL against M. bovis, M. smegmatis and K. pneumonia. In general, the crude extracts showed great activity against Gram-negative and Gram-positive bacteria and novel results for two mycobacteria species M. bovis and M. smegmatis. The results provide evidence of diverse fungal endophytes isolated from Solanum mauritianum, and evidence that fungal endophytes are a good source of bioactive compounds with pharmaceutical potential, particularly against Mycobacterium tuberculosis.

show abstract

Section: Discussionsupporting

confidence: 91%

Diversity and Antimicrobial Activity of Culturable Fungal Endophytes in Solanum mauritianum

Pelo

Mavumengwana

Green

2020

IJERPH

View full text Add to dashboard Cite

show abstract

“…Ponipodef 12 associated with the healthy stems of the “Neva” hybrid of Populus deltoides Marsh × P. nigra L. were collected from Longhua in Hebei Province of China. Compound 83 displayed antifungal effects against the spore germination of M. oryzae with potent inhibition with the IC 50 value of 11.6 µg/mL, which was comparable with the positive control, carbendazim (IC 50 6.9 µg/mL) [ 50 ]. Previously, it found that rhizopycnin D ( 84 ), palmariol B ( 85 ), TMC-264 ( 86 ), penicilliumolide B ( 87 ), and alternariol 9-methyl ether ( 88 ) exhibits antifungal activity against the spore germination of M. oryzae [ 51 , 52 ].…”

Section: Medicinal Plantsmentioning

confidence: 99%

Endophytic Fungi: A Source of Potential Antifungal Compounds

Deshmukh

Gupta

Prakash

et al. 2018

JoF

107

View full text Add to dashboard Cite

The emerging and reemerging forms of fungal infections encountered in the course of allogeneic bone marrow transplantations, cancer therapy, and organ transplants have necessitated the discovery of antifungal compounds with enhanced efficacy and better compatibility. A very limited number of antifungal compounds are in practice against the various forms of topical and systemic fungal infections. The trends of new antifungals being introduced into the market have remained insignificant while resistance towards the introduced drug has apparently increased, specifically in patients undergoing long-term treatment. Considering the immense potential of natural microbial products for the isolation and screening of novel antibiotics for different pharmaceutical applications as an alternative source has remained largely unexplored. Endophytes are one such microbial community that resides inside all plants without showing any symptoms with the promise of producing diverse bioactive molecules and novel metabolites which have application in medicine, agriculture, and industrial set ups. This review substantially covers the antifungal compounds, including volatile organic compounds, isolated from fungal endophytes of medicinal plants during 2013–2018. Some of the methods for the activation of silent biosynthetic genes are also covered. As such, the compounds described here possess diverse configurations which can be a step towards the development of new antifungal agents directly or precursor molecules after the required modification.

show abstract

“…was an interesting producer of larvicidal metabolites. Previously, dibenzo-α-pyrones were identified from this fungus as potent inhibitors of A. aegypti larvae [10]. In the current study, a new structural type of larvicidal metabolites was identified from the same species.…”

Section: Larvicidal Activitiesmentioning

confidence: 68%

“…Ponipodef12 was isolated as an endophytic fungus from the hybrid poplar of Populus deltoides × P. nigra [9]. This endophytic fungus was known to produce benzo-α-pyrones, dibenzo-α-pyrones [10][11][12][13] and 14-membered resorcylic acid lactones [14], and in our previous investigations, among them dibenzo-α-pyrones showed larvicidal activities [10]. Nevertheless, Hyalodendriella sp.…”

Section: Introductionmentioning

confidence: 99%

Hyalodendrins A and B, New Decalin-Type Tetramic Acid Larvicides from the Endophytic Fungus Hyalodendriella sp. Ponipodef12

Mao

Wang

et al. 2019

Molecules

Self Cite

View full text Add to dashboard Cite

Two new decalin/tetramic acid hybrid metabolites, hyalodendrins A (1) and B (2) were isolated from plant endophytic fungus Hyalodendriella sp. Ponipodef12. The structures of the new compounds were elucidated by analysis of the spectroscopic data, including NMR, HRMS and ECD, and by chemical conversion. Compounds 1 and 2 were phomasetin analogues, and both showed potent larvicidal activity against the fourth-instar larvae of Aedes aegypti with the median lethal dose (LC50) values of 10.31 and 5.93 μg/mL, respectively.

show abstract

Dibenzo-α-pyrones: a new class of larvicidal metabolites againstAedes aegyptifrom the endophytic fungusHyalodendriellasp. Ponipodef12

Abstract: Our study revealed dibenzo-α-pyrones to be a new class of larvicidal metabolites against A. aegypti. © 2016 Society of Chemical Industry.

Cited by 26 publications

References 37 publications

Diversity and Antimicrobial Activity of Culturable Fungal Endophytes in Solanum mauritianum

Diversity and Antimicrobial Activity of Culturable Fungal Endophytes in Solanum mauritianum

Endophytic Fungi: A Source of Potential Antifungal Compounds

Hyalodendrins A and B, New Decalin-Type Tetramic Acid Larvicides from the Endophytic Fungus Hyalodendriella sp. Ponipodef12

Contact Info

Product

Resources

About