Dibutyl 2,6-Dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, Diisobutyl 2,6-Dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate and Di-tert-butyl 2,6-Dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

Abstract

The structures of dibutyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, C23H30N206, diisobutyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, C23H30N206, and di-tertbutyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, C23H30N206, members of the 1,4-dihydropyridine class of calcium antagonists, have been determined. Increasing the bulk of the esterification groups, as quantified in a cone-angle analysis, leads to greater perpendicularity of the dual ring system. This leads to conclusions about the potential activity of these compounds. Comment AbstractThe structures of (E)-6-chloro-3-[2-(4-chlorophenylsulfonyl)ethenyl]-4-chromanone, CITHIoC1204S, (E)-6bromo-3-[2-(4-bromophenylsulfonyl)ethenyl]-4-chromanone, C17HIoBr2OnS, and (E)-3-[2-(4-chlorophenylsulfonyl)ethenyl ]-6-methoxy-4-chromanone, C 18 H 13 C105 S, display similar bond angles and distances, but differ in the conformations of the ring systems.

Synthesis, Characterization, Crystal and Molecular Structure Analysis of 2,6-Dimethyl-3-Acetyl-5-Carbomethoxy-4-Phenyl-1,4-Dihydropyridine

“…1,4-Dihydropyridine derivatives (1,4-DHPs) form a class of heterocyclic compounds with interesting pharmacological and biological properties [1][2][3][4][5][6][7][8][9]. It is well known that the 1,4-DHP nucleus serves as the scaffold of important cardiovascular drugs and it has been well established that the calcium modulator activity of this family of compounds is determined by structural requirements [10][11][12][13][14]. The systematic structural modification of the 1,4-DHP ring yields different compounds used in the treatment of hypertension and angina pectoris [15][16][17][18][19][20][21][22][23].…”

“…The C-3 position of phenyl ring of 1,4-dihydropyridine was fixed by NO 2 group [34]. The majority of the tested compounds were found to be the most effective MDR modulators and these derivatives caused a dose-dependent inhibition of the MDR p-glycoprotein [13,35].…”