Dicaffeoylquinic acids in Yerba mate (<i>Ilex paraguariensis</i> St. Hilaire) inhibit NF‐κB nucleus translocation in macrophages and induce apoptosis by activating caspases‐8 and ‐3 in human colon cancer cells

Puangpraphant, Sirima; Berhow, Mark A.; Vermillion, Karl E.; Potts, Greg; Mejía, Elvira González de

doi:10.1002/mnfr.201100128

Cited by 96 publications

(55 citation statements)

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“…Caffeoylquinic acid derivatives inhibited LPS-induced Raw 264.7 macrophage inflammation by suppressing NO/iNOS and prostaglandin E2/cyclooxygenase-2 pathways through inhibiting nucleus translocation of NF-NB subunits, p50 and p65 (Puangpraphant et al, 2011). Tricaffeoylquinic acid seems to attenuate TNF-Į-stimulated inflammatory mediators production by keratinocytes, suppressing the activation of Akt and NF-țB pathways which may be mediated by reactive oxygen species, suggesting that this compound may exert inhibitory effects against the pro-inflammatory mediator-induced skin disease (Lee et al, 2011).…”

Section: Discussionmentioning

confidence: 98%

Propolis and its constituent caffeic acid suppress LPS-stimulated pro-inflammatory response by blocking NF-κB and MAPK activation in macrophages

Búfalo

Ferreira

Costa

et al. 2013

Journal of Ethnopharmacology

156

102

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Propolis and its constituent caffeic acid suppress LPS-stimulated pro-inflammatory response by blocking NF-κB and MAPK activation in macrophages, Journal of Ethnopharmacology, http://dx.doi.org/ 10. 1016/j.jep.2013.06.004 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting galley proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. AbstractEthnopharmacological relevance: Propolis is a bee product with numerous biological and pharmacological properties, such as immunomodulatory and anti-inflammatory activities.It has been used in folk medicine as a healthy drink and in food to improve health and prevent inflammatory diseases. However, little is known about its mechanism of action.Thus, the goal of this study was to verify the antioxidant activity and to explore the antiinflammatory properties of propolis by addressing its intracellular mechanism of action.Caffeic acid was investigated as a possible compound responsible for propolis action. Materials and Methods:The antioxidant properties of propolis and caffeic acid were evaluated by using the 2,2-diphenyl-1-picrylhydrazyl free radical (DPPH) scavenging method. To analyze the anti-inflammatory activity, Raw 264.7 macrophages were treated with different concentrations of propolis or caffeic acid, and nitric oxide (NO) production, a strong pro-inflammatory mediator, was evaluated by the Griess reaction. The concentrations of propolis and caffeic acid that inhibited NO production were evaluated on intracellular signaling pathways triggered during inflammation, namely p38 mitogenactivated protein kinase (MAPK), c-jun NH 2 -terminal kinase (JNK1/2), the transcription nuclear factor (NF)-NB and extracellular signal-regulated kinase (ERK1/2), through Western blot using specific antibodies. A possible effect of propolis on the cytotoxicity of hepatocytes was also evaluated, since this product can be used in human diets.Results: Caffeic acid showed a higher antioxidant activity than propolis extract. Propolis and caffeic acid inhibited NO production in macrophages, at concentrations without cytotoxicity. Furthermore, both propolis and caffeic acid suppressed LPS-induced signaling pathways, namely p38 MAPK, JNK1/2 and NF-NB. ERK1/2 was not affected by propolis extract and caffeic acid. In addition, propolis and caffeic acid did not induce hepatotoxicity at concentrations with strong anti-inflammatory potential. Conclusions:Propolis exerted an antioxidant and anti-inflammatory action and caffeic acid may be involved in its inhibitory effects on NO production and intracellular signaling cascades, suggesting its use as a natural source of safe anti-inflammatory drugs.

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Section: Discussionmentioning

confidence: 98%

Propolis and its constituent caffeic acid suppress LPS-stimulated pro-inflammatory response by blocking NF-κB and MAPK activation in macrophages

Búfalo

Ferreira

Costa

et al. 2013

Journal of Ethnopharmacology

156

102

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“…Nuclear factor kB (NF-kB) is a transcription factor and essential component link between inflammation and cancer. In innate immune pre-neoplastic and malignant cells, NF-kB upregulates inflammatory cytokines and enzymes including cyclooxygenase-2 (COX-2) and inducible nitric oxide (iNOS), which are an important factor for the synthesis of inflammatory mediators prostaglandin E2 (PGE2), anti-apoptosis, angiogenesis and metastasis (Puangpraphant, Berhow, Vermillion, Potts & Mejia, 2011). Puangpraphant et al (2011) demonstrated that 3,4-, 3,5-and 4,5diCQA fractions shown anti-inflammatory effect by suppressing the COX-2/PGE2 and iNOS/NO pathways.…”

Section: Colon Cancermentioning

confidence: 99%

“…The diCQA fractions inhibited RKO and HT-29 cell proliferation by inducing apoptosis rather than arresting cell cycle. Apoptosis occurs through induction of the ratio of Bax:Bcl-2 protein expression and diCQA induced the cleavage of procaspase-3 to active caspase-3, which is a key step of apoptosis (Puangpraphant et al, 2011 participating in these processes, which involve degradation of environmental barriers such as the extracellular matrix (ECM) and the basement membrane. Weng & Yen (2012) showed that CT26 cells treated with caffeic acid phenyl ester (CAPE) exhibited not only cell invasion inhibition, but also a decrease in matrix metalloproteinase (MMP)-2/-9 and vascular endothelial growth factor (VEGF) productions.…”

Section: Colon Cancermentioning

confidence: 99%

Anticancer Properties of Hydroxycinnamic Acids -A Review

Rocha¹,

Monteiro²,

Teodoro

2012

CCO

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Hydroxycinnamic acid compounds are an important source of antioxidants due to their ubiquitous occurrence in the plant kingdom and their characteristic activities. Due to their antioxidant activity, several researchers have attributed a probable role of these compounds in the prevention of various diseases associated with oxidative stress, such as cancer and cardiovascular diseases. Recent evidence suggests that these compounds may also act by other mechanisms in addition to the antioxidant capacity as modulating the activity of some specific enzymes and inhibit cell proliferation. This paper is a comprehensive review of the effects of hydroxycinnamic acids on cancer. The review encompasses the occurrence and bioavailability of these compounds evidences for their effects on cancer and the various mechanisms by which may exert their effects. There are several common mechanisms by which these chemicals exert their effects that could be conducive to additive, synergistic, or antagonistic interactions. These include effects on cellular differentiation, proliferation, and apoptosis; effects on proteins and enzymes that are involved in these processes at a molecular level, and other various effects through altered immune function and chemical metabolism.

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“…4 With such conflicting data, this review is very relevant and serves to advance our understanding of the association between maté drinking and the risk of oral and pharyngeal cancers.…”

mentioning

confidence: 99%

Maté intake and risk of oral and pharyngeal cancers

Al-Dakkak¹,

Ternouth

2012

Evid Based Dent

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Maté is a common beverage worldwide, especially in Latin America and certain parts of the Middle East. The dried leaves and stemlets of the plant are brewed and consumed hot or cold. Several studies have shown that maté drinking is a risk factor for a number of cancers including oral and pharyngeal cancers. Also, there is a strong evidence base linking maté drinking to oesophageal cancer. [1][2][3] Conversely, maté has been recognised for its antioxidant and anticancer properties. A recent study isolated di-caffeoylquinic acids (diCQAs) from maté leaves to explore their mechanism of action.The results suggest that diCQAs in maté could be potential anti-cancer agents and could mitigate other diseases associated with inflammation. 4 With such conflicting data, this review is very relevant and serves to advance our understanding of the association between maté drinking and the risk of oral and pharyngeal cancers.The review addressed the study question using a well thought out systematic approach.The authors' search strategy included the terms maté, maté drinking, maté beverage, cancer, oral cancer, tongue can-

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Dicaffeoylquinic acids in Yerba mate (Ilex paraguariensis St. Hilaire) inhibit NF‐κB nucleus translocation in macrophages and induce apoptosis by activating caspases‐8 and ‐3 in human colon cancer cells

Abstract: The results suggest that diCQAs in Yerba mate could be potential anti-cancer agents and could mitigate other diseases also associated with inflammation.

Cited by 96 publications

References 51 publications

Propolis and its constituent caffeic acid suppress LPS-stimulated pro-inflammatory response by blocking NF-κB and MAPK activation in macrophages

Propolis and its constituent caffeic acid suppress LPS-stimulated pro-inflammatory response by blocking NF-κB and MAPK activation in macrophages

Anticancer Properties of Hydroxycinnamic Acids -A Review

Maté intake and risk of oral and pharyngeal cancers

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