Dicarbamate Surfactant – Tween 80 Binary Systems: Aggregation, Antimicrobial Activity and Membranotropic Properties

Kushnazarova, R. A.; Mirgorodskaya, A. B.; Voloshina, Alexandra D.; Lyubina, Anna P.; Kuznetsov, Denis M.; Lenina, O. A.; Zakharova, L. Ya.

doi:10.18083/lcappl.2022.2.6

Cited by 3 publications

(2 citation statements)

References 22 publications

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“…The CMC of Tw in pure water is 0.24 mmol/m 3 . These data are in good agreement with those given in the literature [12][13][14]. Some adsorption parameters calculated based on tensiometric measurements are given in Table 2.…”

Section: Discussionsupporting

confidence: 89%

“…When dissolved in water in the concentration range of CTw 0.04-1.28 g/dm 3 , Tw forms colorless solutions with рН 6.2-6.3. Upon contact with water, the hydrophobic chains of Tw molecules are pushed out of the bulk and associate through bonding among hydrocarbon chains, forming aggregates surrounded on the outside by polar groups facing the solvent [13]. When the surface (boundary) l-g is completely filled, micelles begin to form in the bulk of the solution.…”

Section: Discussionmentioning

confidence: 99%

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Colloid-chemical properties of surfactant–nitric acid–water systems

Danilin,

Lugovitskaya,

Kolmachikhina

et al. 2023

Chim.Tech.Acta

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The behavior of the surfactants Tween 80, SaS and alkyl betaine in aqueous and nitric acid environments as promising additives for nitrate leaching of hard-to-process ore concentrates of non-ferrous metals was studied. The influence of surfactant concentration (0.04–1.28 g/dm3), nitric acid concentration (0.1–10 g/dm3) and temperature (295–343 K) on the surface tension, critical micelle concentration (CMC), pH and optical density of aqueous surfactant solutions and surfactant–HNO3–H2O systems was found. The critical micelle concentration of the surfactants used was estimated. A positive effect of nitric acid on the surface activity of surfactants was discovered, which manifests itself in a decrease in both the CMC and the surface tension at the liquid–gas interface. The values of surface activity and Gibbs energy of surfactant micelle formation in aqueous and nitric acid media were calculated. Associative processes in the solutions and compositions were confirmed by measuring the optical density of the systems under study.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Colloid-chemical properties of surfactant–nitric acid–water systems

Danilin,

Lugovitskaya,

Kolmachikhina

et al. 2023

Chim.Tech.Acta

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Improving the Stability, Water Solubility, and Antioxidant Activity of α-Tocopherol by Encapsulating It into Niosomes Modified with Cationic Carbamate-Containing Surfactants

Kushnazarova,

Mirgorodskaya,

Bushmeleva

et al. 2024

Langmuir

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The low solubility of α-tocopherol in water and its susceptibility to photodegradation make it difficult for biological systems to absorb this natural antioxidant. To overcome these limitations, αtocopherol was encapsulated in low-toxicity nanocontainers, namely, niosomes based on Tween 80 and cholesterol. The niosomes were modified with cationic surfactants containing a carbamate fragment. The size and charge of the particles were determined and their stability was assessed using dynamic and electrophoretic light scattering methods. It was found that the introduction of cationic surfactants to niosome formulations significantly improved their physicochemical properties and increased stability due to a positive charge of up to +40 mV being generated. Modified niosomes loaded with α-tocopherol were characterized by a hydrodynamic diameter of 100−120 nm, a narrow particle size distribution, and a high encapsulation efficiency of more than 90%. Testing the photochemical stability of α-tocopherol using a spectrophotometric method demonstrated that niosomes were able to protect this substance from UV irradiation. Luminescence analysis showed that the inclusion of α-tocopherol in niosomes increased their antioxidant activity by 30%. An acute toxicity study has demonstrated the safety of the systems. The LD 50 value for niosomes modified with carbamate-containing surfactants and loaded with α-tocopherol exceeded 10,000 mg•kg −1 (mice, intraperitoneal and oral administration).

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Obtaining emulsions of furanocoumarins from Sosnowsky’s hogweed and <i>in vitro</i> assessment of their phototoxic effect

Shlyapkina,

Kulikov,

Brodovskaya

et al. 2023

Acta biomedica scientifica

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Background. Furanocoumarin-based drugs are used for photochemotherapy of various diseases. Sosnovsky’s hogweed can be an available source of furanocoumarins for the development of drugs.The aim of the study. To obtain stable emulsions containing furanocoumarins from Sosnowski’s hogweed and to evaluate their photocytotoxicity.Materials and methods. To obtain the emulsions, furanocoumarins were extracted with chloroform from the sap of the aerial part of the Sosnowski’s hogweed. The chloroform extract was clarified by silica gel gradient column chromatography. The extractive fraction containing furanocoumarins was analyzed by high performance liquid chromatography with ultraviolet (UV) detection. An extract with a high content of 8-methoxypsoralen was used to prepare two types of emulsions. The extract was dissolved in peach oil and emulsified in water with tween-80 (emulsion No. 1) and in an aqueous glycerin solution with lecithin (emulsion No. 2).The emulsions were tested for dark and photo-induced toxicity for human lung fibroblasts. The dose of UV radiation for the photoactivation of furanocoumarins was 9 J/cm2. A solution of chlorine e6 was used as a comparison photosensitizer.Results. The obtained emulsions contained 1 mg/ml 8-methoxypsoralen. Both emulsions were homogeneous at macro- and microscopic visualization, remained stable when stored under various temperature conditions for 14 days. Emulsion No. 2 did not show dark toxicity and caused a statistically significant inhibition of cell viability under UV irradiation at a concentration of 12.5–31.3 µg/mL. Emulsion No. 1 had a toxic effect on cells regardless of UV irradiation due to the content of tween-80. According to fluorescent microscopy, the phototoxic effect of emulsion No. 2 was manifested mainly due to apoptosis, in contrast to the effect of chlorine e6, in which there were more pronounced signs of cell necrosis.Conclusion. The developed experimental emulsions of furanocoumarins from Sosnovski’s hogweed are an example of promising medicinal photosensitizers of plant origin for phototherapy of various dermatological and oncological diseases.

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Dicarbamate Surfactant – Tween 80 Binary Systems: Aggregation, Antimicrobial Activity and Membranotropic Properties

Cited by 3 publications

References 22 publications

Colloid-chemical properties of surfactant–nitric acid–water systems

Colloid-chemical properties of surfactant–nitric acid–water systems

Improving the Stability, Water Solubility, and Antioxidant Activity of α-Tocopherol by Encapsulating It into Niosomes Modified with Cationic Carbamate-Containing Surfactants

Obtaining emulsions of furanocoumarins from Sosnowsky’s hogweed and <i>in vitro</i> assessment of their phototoxic effect

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