Dicarbofunctionalization of unactivated alkenes via organo-photoredox catalysis in water: access to cyanoalkylated fused quinazolinones

Abstract

A visible-light-induced C-C bond cleavage/addition/cyclization cascade of oxime esters and unactivated alkenes has been developed using water as the solvent. This green protocol offers an easy access to medicinally valuable...

Persulfate-Promoted Carbamoylation/Cyclization of Alkenes: Synthesis of Amide-Containing Quinazolinones

“…In recent years, the radical cascade cyclization reaction of N3-alkenyl-tethered quinazolinones has emerged as an attractive strategy for the synthesis of functionalized ring-fused quinazolinone derivatives [ 33 ]. In this regard, several important functional groups, including alkyl [ 34 , 35 , 36 , 37 ], acyl [ 38 ], fluoralkyl [ 39 , 40 , 41 , 42 , 43 ], sulfonyl [ 44 ], and sulfonamidation groups [ 45 ], were smoothly incorporated into quinazolinone scaffolds ( Scheme 1 a). Despite these advances, the development of efficient and facile methods for the introduction of some other valuable groups to quinazolinone scaffolds is still in high demand.…”