Dicationic liquid mediated synthesis of tetrazoloquinolinyl methoxy phenyl 4-thiazolidinones and their antibacterial and antitubercular evaluation

Deshmukh, A. R. A. S.; Dhumal, Sambhaji T.; Nawale, Laxman; Khedkar, Vijay M.; Sarkar, Dhiman; Mane, Ramrao A.

doi:10.1080/00397911.2018.1564928

Cited by 29 publications

(12 citation statements)

References 58 publications

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“…This thought suggested us to get insight into thiazolidinones and comprehensively review this molecule. Thiazolidinone is a biologically important five-membered heterocyclic ring having different types of biological activities [40,41]. In search of new potentially active agents, lots of thiazolidinones derivatives have been synthesised and evaluated for their antibacterial, particularly antitubercular activity.…”

Section: Discussionmentioning

confidence: 99%

An Insight into 4-Thiazolidinones

Sahu

Upadhyay

Mishra

2021

JPRI

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Aims: This assessment is all about to get imminent into 4-thiazolidinones and comprehensively reviewing this molecule. 4-Thiazolidinones are known for their wide-ranging biological activities. 4 - Thiazolidinones contains thiazolidine ring having carbonyl group in the 4-position. The chemistry of thiazolidinones has drawn scientiﬁc interest through the years because this particular ring system is the core structure in a variety of synthetic compounds with a broad spectrum of biological activities such as anti-bacterial, anti-fungal, insecticidal, anti-epileptic, anti-mycobacterial, anti- inflammatory, anti-parasitic, hypnotic and anti-cancer. Structural modiﬁcations on the 4-thiazolidinone moiety, either by replacing the aryl group with the heteroaryl scaffold or by incorporating different groups and moieties (A&B) on –CH– group of nucleus paving a new pathway for the future research. It necessitates to widely reviewing the structure, chemistry and pharmacological aspects of 4-thiazolidinones.

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Section: Discussionmentioning

confidence: 99%

An Insight into 4-Thiazolidinones

Sahu

Upadhyay

Mishra

2021

JPRI

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“…The product was filtered and washed with water then further purification was done using recrystallized from ethanol. Some of the physical properties and yield of compounds (7)(8)(9)(10)(11)(12) are listed in Table (3.45).…”

Section: Synthesis Of 13-dimethyl-6-[2-(3-substituted Phenyl) Thiazolidin-4-one-3-yl]-pyrimidine-24dione-6-yl (7-12) (Genc Bilgicli Et Almentioning

confidence: 99%

“…Using a round bottom flask (50 mL), a mixture of (0.0021 mol) Schiff bases (1)(2)(3)(4)(5)(6) in THF (10 mL) was added to a well-stirred solution of chloroacetic acid (0.2 g, 0.0021 mol) and mixed thoroughly with catalytic few drops of triethylamine in THF solvent. The solution was refluxed for (12)(13)(14)(15) h., after cooling the solution, the crude precipitate was filtered and recrystallization using ethanol. Some of the physical properties and yield of compounds (13)(14)(15)(16)(17)(18) are listed in Table (3.49).…”

Section: Synthesis Of 13-dimethyl-6-[2-(3-substituted Phenyl) Oxazolidin-5-one-3-yl]-pyrimidine-24dione-6-yl (13-18) (Al-majidi and Hama mentioning

confidence: 99%

“…Thiazolidinones as cholinesterase inhibitors and promising compounds against memory decline in Alzheimer's disease, which is associated with cholinergic dysfunctions in rat brain (da Silva et al, 2020). Also thiazolidinone derivatives used as inhibits oesophageal cancer cell proliferation (Wang et al, 2020), anticervical cancer activity (Abbas and El-Karim, 2019), antitubercular agent (Deshmukh et al, 2019), Antibacterial (Cheddie et al, 2019), Anti-Toxoplasma (Abdizadeh et al, 2020), Anti-Cytotoxicity and Anti-inflammatory (Shawky et al, 2020) in addition of Anti-hepatitis-C (Hassan et al, 2019). Besides these, oxazolidinones are the latest class of inhibitory effects exerted on the mitochondrial function of megakaryoblastic cells appear to be particularly protracted (Milosevic et al, 2019) and treatment of skin and skin Structure infections (Santos et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

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Synthesis, Characterization Of Thiazolidin-4-one, Oxazolidin-4-one And Imidazolidin-4-one Derivatives From 6-Amino-1, 3-dimethyluraciland Evaluation Of Their Antioxidant And Antimicrobial Agent

Al-Adhami

Al-Majidi²

2021

Al-Qadisiyah Journal of Pure Science

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In this study, a new series of 6-amino-1,3-dimethyluracil derivative with 6-(3-substituted N-benzylidene)-1,3-dimethyl pyrimidine-2,4-dione-6-yl derivatives which were synthesized by using one pot synthesis. The reaction of 6-amino-1,3-dimethyluracil and different aromatic aldehyde in ethanol yielded Schiff bases (1-6). In the subsequent step reaction of Schiff bases )1-6) with 2-mercaptoacetic acid, 2-chloroacetic acid and 2-amino acetic acidn in Tetrahydrofuran yielded five membered heterocyclic rings of 6-amino-1,3-dimethyluracil derivative which includes: 2,3-thiazolidin-4-one (7-12), 2,3-oxazolidin-5-one (13-18), 2,3-imidazolidin-4-one (19-24) derivatives. The structures of newly synthesized compounds were confirmed by their physicochemical and spectral means FTIR, 1HNMR and 13CNMR. The synthesized compounds were evaluated in vitro for antioxidant and antimicrobial activities against four types of bacteria and four types of fungi

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“…[2][3][4][5][6]. Moreover, many researchers demonstrated that 4-thiazolidinones ( Figure 1) have significant antitubercular activity [7][8][9][10][11][12][13][14].…”

Section: Introductionmentioning

confidence: 99%

5-Methyl-4-thiazolidinones: Synthesis and evaluation as antitubercular agents

Ekinci¹,

Moncóľ²,

Krishna³

et al. 2020

jrp

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This paper reports the synthesis, characterization and evaluation of some 5-methyl-4-thiazolidinone derivatives for their in vitro antimycobacterial activities against Mycobacterium tuberculosis H37Rv strain by microplate alamar blue assay. Also the crystal structures of the compounds (2a and 2c) were determined by the single-crystal Xray diffraction study. Among the target compounds, 2-(4-ethoxyphenyl)-5-methyl-3-(phenylamino)thiazolidin-4-one (2g) was promising with a minimum inhibitory concentration of 12.5 μg/mL against M. tuberculosis. Based on the preliminary results, 2g was considered as a lead compound for further optimization of antimycobacterial activity.

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Dicationic liquid mediated synthesis of tetrazoloquinolinyl methoxy phenyl 4-thiazolidinones and their antibacterial and antitubercular evaluation

Cited by 29 publications

References 58 publications

An Insight into 4-Thiazolidinones

An Insight into 4-Thiazolidinones

Synthesis, Characterization Of Thiazolidin-4-one, Oxazolidin-4-one And Imidazolidin-4-one Derivatives From 6-Amino-1, 3-dimethyluraciland Evaluation Of Their Antioxidant And Antimicrobial Agent

5-Methyl-4-thiazolidinones: Synthesis and evaluation as antitubercular agents

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