Dichloroacetate Decreases Cell Health and Activates Oxidative Stress Defense Pathways in Rat Alveolar Type II Pneumocytes

Valauri-Orton, Alexis; Bschorer, Frizzi; Bernd, Karen K.

doi:10.1155/2015/129031

Cited by 1 publication

(1 citation statement)

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“…Dichloroacetate (DCA), a xenobiotic, have hepatocarcinogenic and hepatotoxicant effects that causes damage to macrophages [ 8 ]. It also induces peripheral neuropathy in the form of painful sensations, tingling, and numbness in the extremities in addition to slowing nerve conduction [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Effectiveness of low-power laser therapy in improvement of the peripheral neuropathy induced by xenobiotics in rats

Mannaa

Abdel-Wahhab

Daoud

et al. 2021

Biochemistry and Biophysics Reports

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Background Peripheral neuropathy (PN) is the damage and dysfunction of neurons of the peripheral nervous system. The present study was conducted to estimate the effectiveness of low-power laser therapy (LPLT) in the management of PN in a rats’ model. Methods PN was induced by giving dichloroacetate (DCA) (250 mg/kg/day) for up to 12 weeks. Four groups of rats were used: control group, PN group, PN group treated with gabapentin and PN group treated with LPLT. The study was conducted for 8 weeks. The management of PN was estimated by behavioral tests which included hot plate and Morris water maze tests. Blood biochemical analysis were carried out. Results Using of hot plate test indicated thermal hypoalgesia and using Morris water maze test showed cognitive decline in PN rats. Treatment with LPLT or gabapentin improved both the pain sensations and deteriorated memory that occurred in the PN rats. Biochemical analysis showed that LPLT significantly decreased the elevated beta-endorphin level in PN rats, while gabapentin could not reduce it. Treatment PN rats with LPLT or gabapentin shifted the high levels of TNF-α, IL-1β and IL-10 cytokines back to their normal values. Serum nitric oxide and MDA significantly increased in the PN group together with significant reduction in the rGSH level, these values were significantly improved by LPLT application while this was not the case with gabapentin treatment. Furthermore, treatment with gabapentin or LPLT significantly reduced serum ALAT and ASAT activities which are otherwise increased in the PN group. S100B, PGE2, total cholesterol, triglycerides, LDL-cholesterol, HDL-cholesterol, urea and creatinine showed insignificant changes among all groups. Conclusions Our results showed that treatment with LPLT is more efficient than gabapentin in ameliorating the peripheral neuropathy induced by xenobiotics.

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Section: Introductionmentioning

confidence: 99%