Dichlorodiphenyltrichloroethane (DDT) induced extracellular vesicle formation: a potential role in organochlorine increased risk of Parkinson's disease

Rossi, Mario; Scarselli, Marco; Fasciani, Irene; Maggio, Roberto; Giorgi, Franco

doi:10.21307/ane-2017-043

Cited by 8 publications

(3 citation statements)

References 35 publications

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“…concentrations of DDT (Von Bartheld and Altick, 2011).The discovery of this new property of DDT has led to the suggestion that this mechanism could explain the increased risk of neurodegenerative diseases in patients exposed to DDT(Rossi et al, 2017; Pietrantoni et al, 2018). A relationship between organochlorine pesticide exposure and neurodegenerative diseases has been proposed by several epidemiological studies(Fleming et al, 1994;Chhillar et al, 2013;Singh et al, 2013;Richardson et al, 2014].…”

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confidence: 99%

Neurotoxic and Neuroprotective Role of Exosomes in Parkinson’s Disease

Longoni

Fasciani

Kolachalam

et al. 2020

CPD

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: Exosomes are extracellular vesicles produced by eukaryotic cells that are also found in most biological fluids and tissues. While they were initially thought to act as compartments for removal of cellular debris, they are now recognized as important tools for cell-to-cell communication and for the transfer of pathogens between the cells. They have attracted particular interest in neurodegenerative diseases for their potential role in transferring prion-like proteins between neurons, and in Parkinson’s disease (PD), they have been shown to spread oligomers of α-synuclein in the brain accelerating the progression of this pathology. A potential neuroprotective role of exosomes has also been equally proposed in PD as they could limit the toxicity of α-synuclein by clearing them out of the cells. Exosomes have also attracted considerable attention for use as drug vehicles. Being nonimmunogenic in nature, they provide an unprecedented opportunity to enhance the delivery of incorporated drugs to target cells. In this review, we discuss current knowledge about the potential neurotoxic and neuroprotective role of exosomes and their potential application as drug delivery systems in PD.

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confidence: 99%

Neurotoxic and Neuroprotective Role of Exosomes in Parkinson’s Disease

Longoni

Fasciani

Kolachalam

et al. 2020

CPD

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“…Use of pesticides linked to PD decreased in the country. The Netherlands was among the first countries in the world to ban paraquat [ 131 ], and use of other pesticides linked to PD, such as DDT [ 132 ] and dieldrin [ 133 ], also fell. Levels of these pesticides and their metabolites in the blood, fat, and breast milk of Dutch citizens declined.…”

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confidence: 99%

Parkinson’s Disease Is Predominantly an Environmental Disease

Dorsey,

Bloem

2024

Journal of Parkinson’s Disease

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Parkinson’s disease is the world’s fastest growing brain disorder, and exposure to environmental toxicants is the principal reason. In this paper, we consider alternative, but unsatisfactory, explanations for its rise, including improved diagnostic skills, aging populations, and genetic causes. We then detail three environmental toxicants that are likely among the main causes of Parkinson’s disease— certain pesticides, the solvent trichloroethylene, and air pollution. All three environmental toxicants are ubiquitous, many affect mitochondrial functioning, and all can access humans via various routes, including inhalation and ingestion. We reach the hopeful conclusion that most of Parkinson’s disease is thus preventable and that we can help to create a world where Parkinson’s disease is increasingly rare.

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“…Globally, there is growing evidence suggesting the link between these compounds and the occurrence of various noncancerous and cancerous health outcomes. Among many adverse health effects, there is growing concern about the possible association between serum POPs and reproductive health, wheezing in infants or children, Type 2 diabetes mellitus (DMT2), liver cancer, breast cancer and more recently, Parkinson’s disease [ 4 , 5 , 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

Predictors of Maternal Serum Concentrations for Selected Persistent Organic Pollutants (POPs) in Pregnant Women and Associations with Birth Outcomes: A Cross-Sectional Study from Southern Malawi

Mwapasa

Huber

Chakhame

et al. 2023

IJERPH

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Population exposure to persistent organic pollutants (POPs) may result in detrimental health effects, especially to pregnant women, developing foetuses and young children. We are reporting the findings of a cross-sectional study of 605 mothers in their late pregnancy, recruited between August 2020 and July 2021 in southern Malawi, and their offspring. The aim was to measure the concentrations of selected POPs in their maternal serum and indicate associations with social demographic characteristics and birth outcomes. A high level of education was the main predictor of p,p′-DDE (p = 0.008), p,p′-DDT (p < 0.001), cis-NC (p = 0.014), o,p′-DDT (p = 0.019) and o,p′-DDE (p = 0.019) concentrations in maternal serum. Multiparity was negatively associated with o,p′-DDE (p = 0.021) concentrations. Maternal age was also positively associated (p,p′-DDE (p = 0.013), o,p′-DDT (p = 0.017) and o,p′-DDE (p = 0.045) concentrations. Living in rural areas was inversely associated with high maternal serum concentrations of p,p′-DDT (p < 0.001). Gestational age was positively associated with p,p′-DDE (p = 0.031), p,p′-DDT (p = 0.010) and o,p′-DDT (p = 0.022) concentrations. Lastly, an inverse association was observed between head circumference and t-NC (p = 0.044), Oxychlordane (p = 0.01) and cis-NC (p = 0.048). These results highlight the need to continue monitoring levels of POPs among vulnerable populations in the southern hemisphere.

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Dichlorodiphenyltrichloroethane (DDT) induced extracellular vesicle formation: a potential role in organochlorine increased risk of Parkinson's disease

Cited by 8 publications

References 35 publications

Neurotoxic and Neuroprotective Role of Exosomes in Parkinson’s Disease

Neurotoxic and Neuroprotective Role of Exosomes in Parkinson’s Disease

Parkinson’s Disease Is Predominantly an Environmental Disease

Predictors of Maternal Serum Concentrations for Selected Persistent Organic Pollutants (POPs) in Pregnant Women and Associations with Birth Outcomes: A Cross-Sectional Study from Southern Malawi

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