Dichotomy in Growth and Invasion from Low- to High-Grade Glioma Cellular Variants

Ghosh, Krishnendu; Ghosh, Suchandrima; Chatterjee, Uttara; Bhattacharjee, Pritha; Ghosh, Anirban

doi:10.1007/s10571-021-01096-1

Cited by 3 publications

(2 citation statements)

References 57 publications

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“…The predominant phenotype of tumor-associated macrophages (TAMs) in the tumor microenvironment during glioma onset and early stages remains unclear ( Kennedy et al., 2013 ). Nevertheless, studies indicate that M2 TAM infiltration increases with glioma progression ( Mahlbacher et al., 2018 ; Yin et al., 2020 ; Ghosh et al., 2022 ). Glioma cell proliferation, including glioma stem cells ( Yi et al., 2011 ), results in the secretion of cytokines and chemokines such as MIC-1, periostin, IL-33, and MCP-1 ( Wu et al., 2010 ; Zhou et al., 2015 ; Roesch et al., 2018 ; De Boeck et al., 2020 ), which recruit blood-borne monocytes and macrophages to the tumor site, polarizing them into M2 TAMs.…”

Section: Tumor-associated Microglia/macrophagesmentioning

confidence: 99%

Immunosuppressive cells in oncolytic virotherapy for glioma: challenges and solutions

Liu

Piranlioglu

et al. 2023

Front. Cell. Infect. Microbiol.

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Glioblastoma is a highly aggressive form of brain cancer characterized by the abundance of myeloid lineage cells in the tumor microenvironment. Tumor-associated macrophages and microglia (TAM) and myeloid-derived suppressor cells (MDSCs), play a pivotal role in promoting immune suppression and tumor progression. Oncolytic viruses (OVs) are self-amplifying cytotoxic agents that can stimulate local anti-tumor immune responses and have the potential to suppress immunosuppressive myeloid cells and recruit tumor-infiltrating T lymphocytes (TILs) to the tumor site, leading to an adaptive immune response against tumors. However, the impact of OV therapy on the tumor-resident myeloid population and the subsequent immune responses are not yet fully understood. This review provides an overview of how TAM and MDSC respond to different types of OVs, and combination therapeutics that target the myeloid population to promote anti-tumor immune responses in the glioma microenvironment.

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Section: Tumor-associated Microglia/macrophagesmentioning

confidence: 99%

Immunosuppressive cells in oncolytic virotherapy for glioma: challenges and solutions

Liu

Piranlioglu

et al. 2023

Front. Cell. Infect. Microbiol.

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“…In the revised version of the World Health Organization's (WHO) classification of malignancies affecting the central nervous system (CNS) [ 4 , 5 ], gliomas are classified based on combined molecular and histological findings [ 6 ], which include isocitrate dehydrogenase (IDH) mutation, 1p19q codeletion, H3 Lys27Met, and RELA fusion. Despite the development of molecular biology techniques, modern methods for pathogenesis, and diverse treatments of glioma [ 7 ], it is still a fatal disease with a very poor prognosis [ 8 ] and a mortality rate close to 80% in the first year of diagnosis. Through an excessive generation of reactive oxygen species (ROS), oxidative stress (OS) is a significant contributor to the onset and progression of cancers.…”

Section: Introductionmentioning

confidence: 99%

Comprehensive Prognostic Analysis of Immune Implication Value and Oxidative Stress Significance of NECAP2 in Low-Grade Glioma

Chen

et al. 2022

Oxidative Medicine and Cellular Longevity

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Adaptin ear-binding coat-associated protein 2 (NECAP2) belongs to the family of proteins encoding adaptin-ear-binding coat-associated proteins. However, its immune effect on tumors and its microenvironment are still unclear. Here, we systematically evaluated the differences (variations) in NECAP2 expression for low-grade glioma (LGG) and pan-cancer in the LGG dataset of The Cancer Genome Atlas (TCGA) utilizing bioinformatics methods. We found for the first time that NECAP2 level was elevated in gliomas and that this upregulation increased as the tumor grade increased. In addition, Pearson correlations of NECAP2 with five immune pathways and significant gene mutations associated with NECAP2 were also analyzed. Univariate survival and multivariate Cox analyses were used to compare the clinical characteristics and survival of the patients. Glioma patients with NECAP2 overexpression have a remarkably higher risk of developing malignant behavior and a worse prognosis. The correlation between the expression levels of NECAP2 and the prognosis of glioma patients was identified. Kaplan-Meier curves showed that patients with upregulated NECAP2 expression exhibited an unfavorable prognosis. Western blotting showed that NECAP2 was overexpressed in glioma patients. IHC staining results illustrated an elevation in the NECAP2 protein expression level with the development of tumor malignancy. Additionally, qRT-PCR verified that oxidative stress in glioma tissues reduced the expression of stress-related genes and oxidative stress capacity compared to normal tissues, which may be associated with tumor evasion of immune surveillance and tumor progression. In vitro wound-healing and Transwell assay confirmed that NECAP2 promotes glioma cell migration and invasion. Our study also thoroughly examined the immune significance of NECAP2 in the TCGA-LGG samples, using CIBERSORT and ESTIMATE to explore the correlation between NECAP2 and cancer immune infiltration. The NECAP2 expression levels were correlated with the infiltration degree of immune cells such as neutrophils, CD4+ T cells, macrophages, CD8+ T cells, and B cells. Therefore, our results indicate that NECAP2 strongly correlates with the overall immune infiltration level of glioma and could independently serve as a prognostic biological marker for glioma patients.

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Study of the relationship among biomarkers, cell and tissue of glioma through Raman spectroscopy

Ge,

Wang,

et al. 2025

Spectrochimica Acta Part A: Molecular and Biomolecular Spectros

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Dichotomy in Growth and Invasion from Low- to High-Grade Glioma Cellular Variants

Cited by 3 publications

References 57 publications

Immunosuppressive cells in oncolytic virotherapy for glioma: challenges and solutions

Immunosuppressive cells in oncolytic virotherapy for glioma: challenges and solutions

Comprehensive Prognostic Analysis of Immune Implication Value and Oxidative Stress Significance of NECAP2 in Low-Grade Glioma

Study of the relationship among biomarkers, cell and tissue of glioma through Raman spectroscopy

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