Dickkopf-1 enhances migration of HEK293 cell by beta-catenin/E-cadherin degradation

Kuang, Haibin; Miao, Changxing; Guo, Weixiang; Sha, Peng; Cao, Yujing; Duan, Enkui

doi:10.2741/3373

Cited by 31 publications

(19 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Isoflavone genistein also inhibited the expression of Wnt-5a (130), suggesting that genistein can also modulate Wnt signaling. More recently, genistein was found to inhibit Dkk-1, an antagonist of the Wnt/␤-catenin signaling, by restoring membrane localization of E-cadherin and ␤-catenin in vitro (68). Finally, genistein has also been shown to be effective in the regulation of Hedgehog pathway (123).…”

Section: Natural Products and Human Healthmentioning

confidence: 95%

Chemoprevention in Gastrointestinal Physiology and Disease. Natural products and microbiome

Greiner

Papineni

Umar

2014

American Journal of Physiology-Gastrointestinal and Liver Physi

View full text Add to dashboard Cite

The human intestinal tract harbors a complex ecosystem of commensal bacteria that play a fundamental role in the well-being of their host. There is a general consensus that diet rich in plant-based foods has many advantages in relation to the health and well-being of an individual. In adults, diets that have a high proportion of fruit and vegetables and a low consumption of meat are associated with a highly diverse microbiota and are defined by a greater abundance of Prevotella compared with Bacteroides, whereas the reverse is associated with a diet that contains a low proportion of plant-based foods. In a philosophical term, our consumption of processed foods, widespread use of antibiotics and disinfectants, and our modern lifestyle may have forever altered our ancient gut microbiome. We may never be able to identify or restore our microbiomes to their ancestral state, but dietary modulation to manipulate specific gut microbial species or groups of species may offer new therapeutic approaches to conditions that are prevalent in modern society, such as functional gastrointestinal disorders, obesity, and age-related nutritional deficiency. We believe that this will become an increasingly important area of health research.

show abstract

Section: Natural Products and Human Healthmentioning

confidence: 95%

Chemoprevention in Gastrointestinal Physiology and Disease. Natural products and microbiome

Greiner

Papineni

Umar

2014

American Journal of Physiology-Gastrointestinal and Liver Physi

View full text Add to dashboard Cite

show abstract

“…A large number of experimental studies from our laboratory and others have shown that isoflavones, particularly genistein and daidzein, elicit anti-tumor effects by targeting NF-κB, Wnt, Notch-1, and Akt pathways in many cancers [207,415-420]. Due to its anti-tumor properties, isoflavones have been proposed as potential HIF-1 inhibitor.…”

Section: Natural Product-based Hif Inhibitorsmentioning

confidence: 99%

The biological kinship of hypoxia with CSC and EMT and their relationship with deregulated expression of miRNAs and tumor aggressiveness

Bao

Azmi

Ali

et al. 2012

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer

129

139

View full text Add to dashboard Cite

Hypoxia is one of the fundamental biological phenomena that are intricately associated with the development and aggressiveness of a variety of solid tumors. Hypoxia-inducible factors (HIF) function as a master transcription factor, which regulates hypoxia responsive genes and has been recognized to play critical roles in tumor invasion, metastasis, and chemo-radiation resistance, and contributes to increased cell proliferation, survival, angiogenesis and metastasis. Therefore, tumor hypoxia with deregulated expression of HIF and its biological consequence lead to poor prognosis of patients diagnosed with solid tumors, resulting in higher mortality, suggesting that understanding of the molecular relationship of hypoxia with other cellular features of tumor aggressiveness would be invaluable for developing newer targeted therapy for solid tumors. It has been well recognized that cancer stem cells (CSCs) and epithelial-to-mesenchymal transition (EMT) phenotypic cells are associated with therapeutic resistance and contribute to aggressive tumor growth, invasion, metastasis and believed to be the cause of tumor recurrence. Interestingly, hypoxia and HIF signaling pathway are known to play an important role in the regulation and sustenance of CSCs and EMT phenotype. However, the molecular relationship between HIF signaling pathway with the biology of CSCs and EMT remains unclear although NF-κB, PI3K/Akt/mTOR, Notch, Wnt/β-catenin, and Hedgehog signaling pathways have been recognized as important regulators of CSCs and EMT. In this article, we will discuss the state of our knowledge on the role of HIF-hypoxia signaling pathway and its kinship with CSCs and EMT within the tumor microenvironment. We will also discuss the potential role of hypoxia-induced microRNAs (miRNAs) in tumor development and aggressiveness, and finally discuss the potential effects of nutraceuticals on the biology of CSCs and EMT in the context of tumor hypoxia.

show abstract

“…Sufficient data from in vitro and in vivo experimental studies have produced solid evidence supporting the role of genistein as a potent anti-tumor agent by targeting multiple signaling pathways such as NF-κB, Wnt, Notch-1, and Akt/mTOR in many different types of cancers [193–199]. Accumulating evidence from multiple in vitro and in vivo studies has also indicated that genistein exerts an anti-oxidant activity by inhibition of ROS production, DNA oxidation, lipid peroxidation, and NF-κB-mediated inflammatory cytokines in various cells including cancer cells [200–207].…”

Section: Genistein a Soy Isoflavone As A Potent Anti-oxidant Agenmentioning

confidence: 99%

Targeting CSCs in Tumor Microenvironment: The Potential Role of ROS-Associated miRNAs in Tumor Aggressiveness

Bao¹,

Azmi²,

Li³

et al. 2013

CSCR

View full text Add to dashboard Cite

Reactive oxygen species (ROS) have been widely considered as critical cellular signaling molecules involving in various biological processes such as cell growth, differentiation, proliferation, apoptosis, and angiogenesis. The homeostasis of ROS is critical to maintain normal biological processes. Increased production of ROS, namely oxidative stress, due to either endogenous or exogenous sources causes irreversible damage of bio-molecules such as DNA, proteins, lipids, and sugars, leading to genomic instability, genetic mutation, and altered gene expression, eventually contributing to tumorigenesis. A great amount of experimental studies in vitro and in vivo have produced solid evidence supporting that oxidative stress is strongly associated with increased tumor cell growth, treatment resistance, and metastasis, and all of which contribute to tumor aggressiveness. More recently, the data have indicated that altered production of ROS is also associated with cancer stem cells (CSCs), epithelial-to-mesenchymal transition (EMT), and hypoxia, the most common features or phenomena in tumorigenesis and tumor progression. However, the exact mechanism by which ROS is involved in the regulation of CSC and EMT characteristics as well as hypoxia- and, especially, HIF-mediated pathways is not well known. Emerging evidence suggests the role of miRNAs in tumorigenesis and progression of human tumors. Recently, the data have indicated that altered productions of ROS are associated with deregulated expression of miRNAs, suggesting their potential roles in the regulation of ROS production. Therefore, targeting ROS mediated through the deregulation of miRNAs by novel approaches or by naturally occurring anti-oxidant agents such as genistein could provide a new therapeutic approach for the prevention and/or treatment of human malignancies. In this article, we will discuss the potential role of miRNAs in the regulation of ROS production during tumorigenesis. Finally, we will discuss the role of genistein, as a potent anti-tumor agent in the regulation of ROS production during tumorigenesis and tumor development.

show abstract

Dickkopf-1 enhances migration of HEK293 cell by beta-catenin/E-cadherin degradation

Cited by 31 publications

References 32 publications

Chemoprevention in Gastrointestinal Physiology and Disease. Natural products and microbiome

Chemoprevention in Gastrointestinal Physiology and Disease. Natural products and microbiome

The biological kinship of hypoxia with CSC and EMT and their relationship with deregulated expression of miRNAs and tumor aggressiveness

Targeting CSCs in Tumor Microenvironment: The Potential Role of ROS-Associated miRNAs in Tumor Aggressiveness

Contact Info

Product

Resources

About