Dickkopf-1 Expression in Androgenetic Alopecia and Alopecia Areata in Male Patients

Mahmoud, Enas Abulkheir; Elgarhy, Lamia Hamouda; Hasby, Eiman Adel; Mohammad, Laila

doi:10.1097/dad.0000000000001266

Cited by 19 publications

(28 citation statements)

References 25 publications

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“…Moreover, the anti-DKK1 neutralizing antibody substantially decreased the inhibition of ORS cells’ growth. As previously mentioned, DKK1 concentration is increased in the bald scalp of AGA patients compared with the haired scalp of AGA patients [ 10 , 40 ]. Besides, DHT-influenced DKK1 augmentation has been demonstrated to enhance the apoptosis of keratinocytes in vitro [ 10 ].…”

Section: Dkk1 Implication In Agamentioning

confidence: 99%

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Perspectives on miRNAs Targeting DKK1 for Developing Hair Regeneration Therapy

Papukashvili

Rcheulishvili

Liu

et al. 2021

Cells

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Androgenetic alopecia (AGA) remains an unsolved problem for the well-being of humankind, although multiple important involvements in hair growth have been discovered. Up until now, there is no ideal therapy in clinical practice in terms of efficacy and safety. Ultimately, there is a strong need for developing a feasible remedy for preventing and treating AGA. The Wnt/β-catenin signaling pathway is critical in hair restoration. Thus, AGA treatment via modulating this pathway is rational, although challenging. Dickkopf-related protein 1 (DKK1) is distinctly identified as an inhibitor of canonical Wnt/β-catenin signaling. Thus, in order to stimulate the Wnt/β-catenin signaling pathway, inhibition of DKK1 is greatly demanding. Studying DKK1-targeting microRNAs (miRNAs) involved in the Wnt/β-catenin signaling pathway may lay the groundwork for the promotion of hair growth. Bearing in mind that DKK1 inhibition in the balding scalp of AGA certainly makes sense, this review sheds light on the perspectives of miRNA-mediated hair growth for treating AGA via regulating DKK1 and, eventually, modulating Wnt/β-catenin signaling. Consequently, certain miRNAs regulating the Wnt/β-catenin signaling pathway via DKK1 inhibition might represent attractive candidates for further studies focusing on promoting hair growth and AGA therapy.

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Section: Dkk1 Implication In Agamentioning

confidence: 99%

“…As previously mentioned, DKK1 overexpression is evidenced in the scalp of patients with AGA. Thus, it represents the key protein in the development of AGA [ 40 ].…”

Section: The Importance Of Wnt/β-catenin Signaling In Hair Growthmentioning

confidence: 99%

Perspectives on miRNAs Targeting DKK1 for Developing Hair Regeneration Therapy

Papukashvili

Rcheulishvili

Liu

et al. 2021

Cells

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“…Subsequent studies have reported that genetic ablation of β-catenin gene in epidermis leads to the failure of placode morphogenesis in mice [ 24 ], suggesting the importance of Wnt signals in hair development. Andl and colleagues [ 35 ] generated transgenic mice having epidermal basal cell-specific ectopic expression of Dickkopf 1 (DKK1), which inhibits Wnt action [ 36 , 37 , 38 , 39 , 40 ] by binding with LRP co-receptor, to evaluate the role of Wnt in HF. This study reported that skin-specific overexpression of DKK1 leads to an early and complete block in the development of skin appendages including all types of hair follicles, thus suggesting the essential roles of WNT proteins in follicle development.…”

Section: Role Of Wnt/β-catenin Signaling In Hair Growthmentioning

confidence: 99%

“…This study reported that skin-specific overexpression of DKK1 leads to an early and complete block in the development of skin appendages including all types of hair follicles, thus suggesting the essential roles of WNT proteins in follicle development. A significant increase in DKK1 immunostaining was found in leisonal scalp biopsies taken form patients with androgenic alopecia and alopecia areata as compared to healthy control volunteers [ 35 ]. The administration of recombinant human DKK-1 (rhDKK-1) into mouse hypodermis resulted in final hair follicle length and premature onset of catagen, a key feature of male pattern baldness.…”

Section: Role Of Wnt/β-catenin Signaling In Hair Growthmentioning

confidence: 99%

Targeting Wnt/β-Catenin Pathway for Developing Therapies for Hair Loss

Choi

2020

IJMS

141

105

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Persistent hair loss is a major cause of psychological distress and compromised quality of life in millions of people worldwide. Remarkable progress has been made in understanding the molecular basis of hair loss and identifying valid intracellular targets for designing effective therapies for hair loss treatment. Whereas a variety of growth factors and signaling pathways have been implicated in hair cycling process, the activation of Wnt/β-catenin signaling plays a central role in hair follicle regeneration. Several plant-derived chemicals have been reported to promote hair growth by activating Wnt/β-catenin signaling in various in vitro and in vivo studies. This mini-review sheds light on the role of Wnt/β-catenin in promoting hair growth and the current progress in designing hair loss therapies by targeting this signaling pathway.

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“…19,20 DKK-1 is of special interest since a significant increase in DKK1 immunostaining was found in lesional scalp biopsies taken from patients with androgenic alopecia and alopecia areata when compared to healthy control volunteers. 21 It was reported that the administration of recombinant human DKK-1 (rhDKK-1) into mouse hypodermis resulted in premature onset of catagen, a key feature of male pattern baldness. Injection of neutralizing DKK-1 antibody, on the contrary, delayed the anagen to catagen transition in mice.…”

Section: Introductionmentioning

confidence: 99%

Niacinamide Down-Regulates the Expression of DKK-1 and Protects Cells from Oxidative Stress in Cultured Human Dermal Papilla Cells

Choi¹,

Shin²,

Kim³

et al. 2021

CCID

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Purpose: An increasing number of people are suffering from hair loss disorders. Niacinamide has long been used as an active ingredient for anti-hair loss preparations but the exact mechanism has not been clearly elucidated yet. The effects of niacinamide were investigated in cultured human dermal papilla cells (hDPCs). Methods: To investigate the anti-hair loss effect of niacinamide and its molecular mechanisms, Western blot analysis, ELISA, quantitative RT-PCR and immunocytochemistry were performed. To study the protective effects of niacinamide against H 2 O 2 -induced oxidative stress, ROS generation and cytotoxicity were evaluated by DCF-DA assay and LDH release assay, respectively. Minoxidil was used as a positive control. Results: Niacinamide decreased the protein expression level of DKK-1 which promotes regression of hair follicles by inducing catagen. The protein expression levels of cell senescence markers, p21 (CDKN1A) and p16 (CDKN2A) which are related to cell cycle arrest, were decreased. The expression of versican was increased by niacinamide treatment in cultured hDPCs. We have found that niacinamide decreased the H 2 O 2 -induced intracellular ROS production in cultured hDPCs. Moreover, niacinamide decreased the protein expression levels of H 2 O 2 -induced p21 and p16 and diminished the secretion of H 2 O 2 -induced DKK-1. Conclusion:Our data demonstrate that niacinamide could enhance hair growth by preventing oxidative stress-induced cell senescence and premature catagen entry of hair follicles.

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Dickkopf-1 Expression in Androgenetic Alopecia and Alopecia Areata in Male Patients

Cited by 19 publications

References 25 publications

Perspectives on miRNAs Targeting DKK1 for Developing Hair Regeneration Therapy

Perspectives on miRNAs Targeting DKK1 for Developing Hair Regeneration Therapy

Targeting Wnt/β-Catenin Pathway for Developing Therapies for Hair Loss

Niacinamide Down-Regulates the Expression of DKK-1 and Protects Cells from Oxidative Stress in Cultured Human Dermal Papilla Cells

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