Diclazuril, a New Broad Spectrum Anticoccidial Drug in Chickens.

Abstract

Battery trials have confirmed the broad spectrum anticoccidial activity of diclazuril as previously reported in dose titration studies. The advocated dose level of 1 ppm in the diet demonstrated excellent activity against the economically most important Eimeria species. At this dose level, body weight gains were comparable to those of uninfected, unmedicated controls and the oocyst production was negative in most species. Lesion scores and dropping scores were nil or highly reduced. An E. maxima-147 strain, less sensitive to ionophores, also responded well to diclazuril. It was concluded that diclazuril is a promising anticoccidial for the control of all species of coccidia that cause losses to the poultry industry.

Scientific Opinion on the safety and efficacy of Coxiril® (diclazuril) as a feed additive for chickens for fattening

“…To demonstrate the effect of diclazuril in battery and floor pen trials with chickens for fattening, the applicant submitted three studies published by Vanparijs et al (1989aVanparijs et al ( , b, 1990 performed with diclazuril from Clinacox ® .…”

“…A dose titration study in chickens (Vanparijs et al, 1989a) indicated that diclazuril at dosages of 0.5 to 10 mg/kg feed was highly active against all major pathogenic species (E. tenella, E. acervulina, E. necatrix, E. brunetti, E. maxima and E. mitis) and effective in terms of weight gain, suppression of mortality, dropping scores and oocyst counts. An effective dose range of 1 to 10 mg/kg feed was identified after mixed infections with E. tenella and E. acervulina or E. necatrix and E. brunetti in a floor pen study.…”

“…Several battery trials were performed (Vanparijs et al, 1989b) to confirm the efficacy of diclazuril against the most important Eimeria species. It was concluded from the results that a dose level of 1 mg/kg feed is effective against E. tenella, E. acervulina, E. necatrix, E. brunetti, E. maxima and E. mitis.…”

“…Three floor pen trials (Vanparijs et al, 1990) with artificial infection with one or more of the six major pathogenic Eimeria species indicated that diclazuril, at dose levels of 0.5 to 2 mg/kg, had an anticoccidial activity in terms of preventing mortality, suppressing or reducing lesion scores and restoring normal weight gain, as well as productivity.…”

Scientific Opinion on the safety and efficacy of Coxiril® (diclazuril) as a feed additive for turkeys for fattening

“…To demonstrate the effect of diclazuril in battery and floor pen trials with turkeys for fattening, the applicant submitted three studies published by Vanparijs et al (1989aVanparijs et al ( , b, 1990 performed with diclazuril from Clinacox ® .…”