Diclofenac and eugenol hybrid with enhanced anti-inflammatory activity through activating HO-1 and inhibiting NF-κB pathway in vitro and in vivo

Wang, Wei; Wang, Shou-Kai; Wang, Qi; Zhang, Zhe; Li, Bo; Zhou, Zi‐Dan; Zhang, Jianfeng; Lin, Chi‐Feng; Chen, Ting-Xiao; Jin, Zhen; Tang, You‐Zhi

doi:10.1016/j.ejmech.2023.115669

Cited by 8 publications

(1 citation statement)

References 33 publications

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“…Studies found that myristicin and linalool, two main metabolites in Myristica Semen, could exert anti-inflammatory and antioxidant effects by regulating the expression levels of NF-κ B and Nrf-2 ( Tekeli et al, 2018 ; Ismail Abo El-Fadl and Mohamed, 2022 ). Compared to using diclofenac alone, the composite formulation of diclofenac and eugenol could better inhibit the nuclear translocation of NF-κB by activating the Nrf2/heme oxygenase-1 (HO-1) signaling pathway, thereby demonstrating better therapeutic effects against UC ( Wang et al, 2023c ). Zhang et al developed a new phospholipid nanovesicle containing the volatile oil medicine eugenol to treat UC and confirmed that it was more conducive to percutaneous absorption and had better clinical efficacy ( Zhang et al, 2020c ).…”

Section: Research Progress On Metabolites Of Sishen Pill In the Treat...mentioning

confidence: 99%

Sishen Pill and its active phytochemicals in treating inflammatory bowel disease and colon cancer: an overview

Zhang,

Cheng,

Jian

et al. 2024

Front. Pharmacol.

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The incidence of inflammatory bowel disease (IBD) and the associated risk of colon cancer are increasing globally. Traditional Chinese medicine (TCM) treatment has unique advantages. The Sishen Pill, a common Chinese patented drug used to treat abdominal pain and diarrhea, consists mainly of Psoraleae Fructus, Myristicae Semen, Euodiae Fructus, and Schisandra Chinensis. Modern research has confirmed that Sishen Pill and its active secondary metabolites, such as psoralen, myristicin, evodiamine, and schisandrin, can improve intestinal inflammation and exert antitumor pharmacological effects. Common mechanisms in treating IBD and colon cancer mainly include regulating inflammation-related signaling pathways such as nuclear factor-kappa B, mitogen-activated protein kinase, phosphatidylinositol 3-kinase, NOD-like receptor heat protein domain-related protein 3, and wingless-type MMTV integration site family; NF-E2-related factor 2 and hypoxia-inducible factor 1α to inhibit oxidative stress; mitochondrial autophagy and endoplasmic reticulum stress; intestinal immune cell differentiation and function through the Janus kinase/signal transducer and activator of transcription pathway; and improving the gut microbiota and intestinal barrier. Overall, existing evidence suggests the potential of the Sishen pill to improve IBD and suppress inflammation-to-cancer transformation. However, large-scale randomized controlled clinical studies and research on the safety of these clinical applications are urgently required.

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Section: Research Progress On Metabolites Of Sishen Pill In the Treat...mentioning

confidence: 99%

Sishen Pill and its active phytochemicals in treating inflammatory bowel disease and colon cancer: an overview

Zhang,

Cheng,

Jian

et al. 2024

Front. Pharmacol.

View full text Add to dashboard Cite

show abstract

Novel trifluoromethyl ketone derivatives as oral cPLA2/COX-2 dual inhibitors for resolution of inflammation in rheumatoid arthritis

Cai,

Gao,

et al. 2024

Bioorganic Chemistry

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3-(2-Trifluoromethyl-3-aryl-4H-chromen-4-yl)-1H-indoles: Mastering anti-inflammation and analgesia while mitigating gastrointestinal side effects

Cai,

Gao,

Jia

et al. 2024

Bioorganic Chemistry

View full text Add to dashboard Cite

Diclofenac and eugenol hybrid with enhanced anti-inflammatory activity through activating HO-1 and inhibiting NF-κB pathway in vitro and in vivo

Cited by 8 publications

References 33 publications

Sishen Pill and its active phytochemicals in treating inflammatory bowel disease and colon cancer: an overview

Sishen Pill and its active phytochemicals in treating inflammatory bowel disease and colon cancer: an overview

Novel trifluoromethyl ketone derivatives as oral cPLA2/COX-2 dual inhibitors for resolution of inflammation in rheumatoid arthritis

3-(2-Trifluoromethyl-3-aryl-4H-chromen-4-yl)-1H-indoles: Mastering anti-inflammation and analgesia while mitigating gastrointestinal side effects

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