Diclofenac pharmacokinetic meta‐analysis and dose recommendations for surgical pain in children aged 1–12 years

Abstract

Single doses of 0.3 mg·kg(-1) for intravenous, 0.5 mg·kg(-1) for suppositories, and 1 mg·kg(-1) for oral diclofenac in children aged 1-12 years are recommended as they yield a similar AUC to 50 mg in adults.

Synergistic interaction between diclofenac and pyrilamine on nociception, inflammation, and gastric damage in rats

“…In the present study, the efficacy and security of the diclofenac-pyrilamine combination were assessed on the rat formalin test. The diclofenac and pyrilamine oral dose used in the present study appear to be larger than those dose employed clinically (Derry et al 2015;Ortiz 2010;Standing et al 2011). It is probable that the observed difference may be due to species …”

Effect of pre-operative rectal diclofenac suppository on post-operative analgesic requirement in cleft palate repair: A randomised clinical trial

“…[15] A recent metaanalysis on diclofenac dose recommendation for surgical pain in children aged 1–12 years recommends 0.5 mg/kg for rectal diclofenac. [16] In most other studies, children received a second dose of diclofenac after a period ranging from 8 to 12 h from the first dose. We however restricted our study to a single 1 mg/kg dosage after induction as our primary objective was to study the reduction of opioid consumption in the immediate post-operative period, i.e.…”

Interventions for postoperative pain in children: An overview of systematic reviews

“…Most of the reviews (80%) were published after 2010 (Table S3). Six systematic reviews (13%) had only two authors and only one systematic review searched a single database . Affiliations of authors of the included systematic reviews were predominantly based in Europe (46%) and Asia (29%).…”

“…Safety of interventions was reported as conclusive in 14 SRs (31%), with positive conclusive evidence for dexmedetomidine, corticosteroid, epidural analgesia, transversus abdominis plane block, and clonidine . Seven SRs reported equal conclusive safety for epidural infusion, diclofenac intravenous vs ketamine added to opioid analgesia, bupivacaine, ketamine, paracetamol, and dexmedetomidine vs intravenous infusions of various opioid analgesics, oral suspension and suppository of diclofenac, only opioid, normal saline, no treatment, placebo, and midazolam . Negative conclusive statement for safety was reported in one SR for caudal analgesia vs noncaudal regional analgesia …”