Dicoumarol complexes of Cu(II), Fe(II) and Fe(III): preparation, characterization, in‐vitro antibacterial and DNA binding activity

Abstract

were synthesized and characterized using 1 H-NMR, 13 C-NMR, IR spectra, electronic spectra, magnetic measurements and elemental analyses. The ligands, metal salts, complexes, control and standard drug were tested for their in-vitro antibacterial activity against Bacillus cereus, Staphylococcus aureus, Escherichia coli, Bacillus subtilis, Salmonella typhi, and Serratia marcescens. The metal complexes exhibit good activity against bacterial strains compared with parental compounds and moderate compared with the standard drug (ciprofloxacin). In-vitro DNA-binding activity was carried out using agarose gel electrophoresis. The synthesized compounds show effective DNA-binding activity.

Molecular first order hyperpolarizability and vibrational spectral investigation of Warfarin sodium

“…Their complexation ability in respect to different metal ions has been studied and discussed widely in a considerable number of investigations [5][6][7][8][9]. It has been found that the binding of a metal to the coumarin moiety retains or even enhances its biological activity [10][11][12].…”

DNA‐binding, antibacterial and spectral investigations of drug–Fe(II) complexes

“…The ν(C O) peak for A 5 , A 7 and A 8 was observed at ∼1680 cm −1 (cyclic) and ∼1660 cm −1 (acetyl), which was shifted to 1574 cm −1 on formation of complexes. 30 These data were further supported by a ν(M-O) 25 band appearing at ∼510 cm −1 . The band at ∼1478 cm −1 was assigned to δ(C-H) bending of <N-CH 2 -CH 2 -N →.…”

“…The biocidal activities of the ofloxacin, levofloxacin, flucanozole, ligands, metal salts and their complexes were analyzed against various Gram-negative and Gram-positive bacterial cultures of Staphylococcus aureus, Bacillus subtilis, Bacillus cereus, Salmonella typhi, Escherichia coli and Serratia marcescens using the Agar-plate technique. 16,25…”

Humic acid: A Biodegradable Organocatalyst for Solvent‐free Synthesis of Bis(indolyl)methanes, Bis(pyrazolyl)methanes, Bis‐coumarins and Bis‐lawsones

“…[109] In addition, some dicoumarol complexes of Cu (II), Fe (II) and Fe (III), La (III), and Ag (I) have biological activity. [110] Recently, it was established that the cell killing and oxidative stress in pancreatic cancer cells was initiated by inhibition of NAD(P)H:quinone oxidoreductase (NQO1) with biscoumarins. [111] This biologically important moiety can be easily synthesized by the reaction of 4hydroxycoumarin and various aldehydes in the presence of various homogeneous and heterogeneous catalysts.…”