Did you know—why does maximal oxygen uptake increase in humans following endurance exercise training?

Lundby, Carsten; Montero, David

doi:10.1111/apha.13371

Cited by 13 publications

(17 citation statements)

References 27 publications

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“…Improvement in cardiovascular fitness correlates with the amelioration of cognitive functions (Heisz et al, 2017;Nauer et al, 2020). One of the markers for improving cardiovascular fitness is an improvement in VO 2max (Bacon et al, 2013;Lundby and Montero, 2019). Several studies showed that improving VO 2max parameters resulted in better performance in pattern separation tasks (Heisz et al, 2017;Nauer et al, 2020).…”

Section: Discussionmentioning

confidence: 99%

Mild Physical Activity Does Not Improve Spatial Learning in a Virtual Environment

Ben-Zeev

Weiss

Ashri

et al. 2020

Front. Behav. Neurosci.

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It is well-established that physical exercise in humans improves cognitive functions, such as executive functions, pattern separation, and working memory. It is yet unknown, however, whether spatial learning, long known to be affected by exercise in rodents, is also affected in humans. In order to address this question, we recruited 20 healthy young male adults (18–30 years old) divided into exercise and control groups ( n = 10 in each group). The exercise group performed three sessions per week of mild-intensity aerobic exercise for 12 weeks, while the control group was instructed not to engage in any physical activity. Both groups performed maximal oxygen uptake (VO 2max ) tests to assess their cardiovascular fitness at baseline and every 4 weeks through the 12 weeks of the training program. The effects of mild aerobic exercise were tested on performance in two different virtual reality (VR)-based spatial learning tasks: (1) virtual Morris water maze (VMWM) and (2) virtual Radial arm water maze (VRAWM). Subjects were tested in both tasks at baseline prior to the training program and at the end of 12 weeks training program. While the mild-intensity aerobic exercise did not affect subjects' VO 2max parameters, mean time to anaerobic threshold increased for the exercise group compared with control. No effect was observed, however, on performance in the VMWM or VRAWM between the two groups. Based on these results, we suggest that mild-intensity aerobic exercise does not improve spatial learning and memory in young, healthy adults.

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Section: Discussionmentioning

confidence: 99%

Mild Physical Activity Does Not Improve Spatial Learning in a Virtual Environment

Ben-Zeev

Weiss

Ashri

et al. 2020

Front. Behav. Neurosci.

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“…A brief overview over the main signals that facilitate changes in maximal oxygen uptake of the human body (VO 2max )due to endurance training is given by Lundby and Montero. 27 Several groups described that exercise training can alter mitochondrial function. Cardinale et al elucidate the role of mitochondria in muscle oxidative capacity.…”

Section: Mitochondrial Capacit Ymentioning

confidence: 99%

Physical exercise—A toxin‐free complement to cancer therapy

Groeneveld

2021

Acta Physiologica

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“…Most notably, whether the constitutional factors per excellence, i.e., sex and age, alter the fundamental circulatory relationships remains unresolved [ 16 , 19 , 20 ]. As a case in point, the inexorable age-dependent stiffening and remodeling of the cardiovascular system may interact with sex-specific hemodynamic and hematological characteristics [ 16 , 17 , 21 – 23 ], plausibly altering the regulation of and relationship between primary volumetric variables in the systemic circulation [ 18 , 24 , 25 ]. While the prevailing emphasis on molecular cardiology is an ineluctable consequence of technological prowess, sound integrative bases of cardiovascular physiology have yet to be elucidated in a large fraction of the human population.…”

Section: Introductionmentioning

confidence: 99%

Sex and age interaction in fundamental circulatory volumetric variables at peak working capacity

Díaz-Cañestro

Montero

2022

Biol Sex Differ

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Background Whether the fundamental hematological and cardiac variables determining cardiorespiratory fitness and their intrinsic relationships are modulated by major constitutional factors, such as sex and age remains unresolved. Methods Transthoracic echocardiography, central hemodynamics and pulmonary oxygen (O2) uptake were assessed in controlled conditions during submaximal and peak exercise (cycle ergometry) in 85 healthy young (20–44 year) and older (50–77) women and men matched by age-status and moderate-to-vigorous physical activity (MVPA) levels. Main outcomes such as peak left ventricular end-diastolic volume (LVEDVpeak), stroke volume (SVpeak), cardiac output (Qpeak) and O2 uptake (VO2peak), as well as blood volume (BV), BV–LVEDVpeak and LVEDVpeak–SVpeak relationships were determined with established methods. Results All individuals were non-smokers and non-obese, and MVPA levels were similar between sex and age groups (P ≥ 0.140). BV per kg of body weight did not differ between sexes (P ≥ 0.118), but was reduced with older age in men (P = 0.018). Key cardiac parameters normalized by body size (LVEDVpeak, SVpeak, Qpeak) were decreased in women compared with men irrespective of age (P ≤ 0.046). Older age per se curtailed Qpeak (P ≤ 0.022) due to lower heart rate (P < 0.001). In parallel, VO2peak was reduced with older age in both sexes (P < 0.001). The analysis of fundamental circulatory relationships revealed that older women require a higher BV for a given LVEDVpeak than older men (P = 0.024). Conclusions Sex and age interact on the crucial circulatory relationship between total circulating BV and peak cardiac filling, with older women necessitating more BV to fill the exercising heart than age- and physical activity-matched men.

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Did you know—why does maximal oxygen uptake increase in humans following endurance exercise training?

Cited by 13 publications

References 27 publications

Mild Physical Activity Does Not Improve Spatial Learning in a Virtual Environment

Mild Physical Activity Does Not Improve Spatial Learning in a Virtual Environment

Physical exercise—A toxin‐free complement to cancer therapy

Sex and age interaction in fundamental circulatory volumetric variables at peak working capacity

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