Die altersabh�ngige wirkung polychlorierter biphenyle auf die rattenleber

Fleischer, Martin; Meiß, Rüdiger; Robenek, Horst; Themann, H

doi:10.1007/bf00381206

Cited by 8 publications

(2 citation statements)

References 22 publications

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“…The observed loss of ribosomes on many rough membrane systems demonstrated this possibility in the hepatic cells. Similar alterations in membrane systems were determined after application of CC14 (Shinozna, 1971), hexachlorophene (Reid and Hall, 1974) and polychlorinated biphenylene (Fleischer et al, 1979). The alterations on the outer and inner membranes of the mitochondria indicated an uncoupling of the mitochondrial phosphorylation (Caldwell et al, 1972;Cammer and Moore, 1972).…”

Section: Thin Sectionsupporting

confidence: 50%

“…The proliferation and small vesicular to vacuolar dilatation of the smooth endoplasmic reticulum were observed by intoxications with different medica ments (Remmer and Merker, 1963;David, 1970) and with chlorinated hydro carbons (Remmer andMarker, 1963\ David, 1970;Fleischer et al, 1979). This indicated an enzyme induction due to the increased concentration of exogenic substances for metabolism (Remmer and Merker, 1963).…”

Section: Thin Sectionmentioning

confidence: 91%

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A Correlated Thin Section and Freeze-Fracture Study of <i>o</i>-Phenylphenol-Induced Alterations in the Rat Liver

Robenek¹,

Meiß²,

Themann³

et al. 1980

Pathobiology

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The ultrastructural changes in the liver cells of male Wistar rats induced by oral and subcutaneous application of o-phenylphenol were studied electron microscopically using the thin section and freeze-fracture technique. The rats were given the o-phenylphenol once at a dose of 2,500 mg/kg b.w. and were sacrificed 60 h after treatment. In the orally treated animals, alterations in the nuclei and nucleoli of the hepatocytes were the most prominent alterations. Furthermore, an increase in smooth endoplasmic reticulum, lysosomes and microbodies were found. After the subcutaneous injection of o-phenylphenol enlargements of the bile canaliculi, intercellular space and pathological alterations in the mitochondria were seen. A proliferation of the smooth endoplasmic reticulum, an increase of microbodies and a decrease in the rough endoplasmic reticulum could be found. Both groups showed an increase in small intracellular fat droplets in the hepatocytes. In general, the effects of the subcutaneous application on the liver were more pronounced than the effects of the oral application. Freeze-fracture replicas exhibited a disorganization of the zonulae occludentes and an apparent increase in the number and size of gap junctions. These alterations were interpreted as an attempt of the liver cells to counteract the intracanalicular pressure and to increase the mechanical stability of the liver tissue.

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Section: Thin Sectionsupporting

confidence: 50%

Section: Thin Sectionmentioning

confidence: 91%

A Correlated Thin Section and Freeze-Fracture Study of <i>o</i>-Phenylphenol-Induced Alterations in the Rat Liver

Robenek¹,

Meiß²,

Themann³

et al. 1980

Pathobiology

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Ultrastructural morphometric investigations on rat liver of young and adult rats after treatment with technical pentachlorophenol (PCP)

et al. 1980

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Long-term study of liver damage following subcutaneous injection of airborne particle extracts and polycyclic aromatic hydrocarbon fractions

Meiß

Heinrich

Offermann³

et al. 1982

Int. Arch Occup Environ Heath

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Female NMRI mice aged 9-12 weeks were each given a single subcutaneous injection of 0.5 ml of a suspension containing either the total extracts or the polycyclic aromatic hydrocarbon (PAH) fraction of airborne particles. Both the total extracts and PAH fractions contain 3 microgram benzopyrene. After about 15 months the livers were removed from the animals, which had by that time developed tumors at the injection site, and were subjected to electron-microscopical study. The essential alterations were observed in the nucleoli and the cell nuclei, which had greatly proliferated and exhibited irregular nuclear membranes. Advanced fibrosis was observed in central liver specimens of all groups. Marked alterations were also observed in the mitochondria and the mitochondrial cristae as well as in the bile canaliculi, Intracytoplasmic glycogen usually occurred densely clustered along the periphery of the cell. It may be concluded from the observations that both the total extract of atmospheric suspended particulate matter and the PAH fraction cause hematogenic damage to the liver following subcutaneous injection, a finding which cannot be interpreted as metastatic carcinoma.

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Die altersabh�ngige wirkung polychlorierter biphenyle auf die rattenleber

Cited by 8 publications

References 22 publications

A Correlated Thin Section and Freeze-Fracture Study of <i>o</i>-Phenylphenol-Induced Alterations in the Rat Liver

A Correlated Thin Section and Freeze-Fracture Study of <i>o</i>-Phenylphenol-Induced Alterations in the Rat Liver

Ultrastructural morphometric investigations on rat liver of young and adult rats after treatment with technical pentachlorophenol (PCP)

Long-term study of liver damage following subcutaneous injection of airborne particle extracts and polycyclic aromatic hydrocarbon fractions

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