Die Aminosäurenkonzentration in Plasma und Blutzellen während der Therapie mit Coli-L-Asparaginase

Höcker, P; Stacher, A; Weiser, M.

doi:10.1007/bf01631986

Cited by 3 publications

(2 citation statements)

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“…We were able to demonstrate for the first time the deleterious effect of E. coli asparaginase on glutamine homeostasis, which had already been postulated by several investigators [11,23,24], by means of the posttherapeutic courses of the plasma amino acids. From the uniformly observed fall of glutamine to nearly or completely undetectable plasma concentrations, we deduce that this is an obligatory side-effect of this drug.…”

Section: Discussionsupporting

confidence: 53%

See 1 more Smart Citation

Asparaginase‐induced derangements of glutamine metabolism: the pathogenetic basis for some drug‐related side‐effects

Ollenschläger¹,

Roth²,

Linkesch³

et al. 1988

Eur J Clin Investigation

121

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Abstract. Several side-effects of asparaginase therapy have been said to be a consequence of the glutaminase activity of Escherichia coli asparaginase, especially the deleterious influence on the liver function. We report here the drug-induced impairments of asparagine and glutamine metabolism in correlation to concentrations changes of plasma proteins, synthesized in the liver, in patients with acute lymphatic leukaemia. One hour after asparaginase application, plasma glutamine decreased to 5% (0-39%: median, range) of the initial values, with a subsequent rise to concentrations slightly lower than those prior to therapy. During the 14 days of drug application the fasting plasma concentrations of glutamine fell to a median of 63% of the pre-therapeutic levels, indicating a depletion of the glutamine pools. Two days after the end of asparaginase application, in one patient the glutamine concentrations increased to the pre-therapeutic range. Plasma concentrations of fibrinogen and antithrombin I11 decreased to 46% and 56%, respectively, of the initial values, with a slight increase 2 days after the end of therapy. The changes of plasma protein concentrations followed the course of plasma glutamine and asparagine. From that we deduce that the hepatic synthesis of the plasma proteins might be influenced by asparagine and glutamine depletion as a consequence of the therapy with E. coli asparaginase.

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Section: Discussionsupporting

confidence: 53%

“…Despite the great number of studies on asparaginase there are few data available on the effects of E. coli asparaginase administration on plasma amino acid levels in humans [23,24].…”

Section: Discussionmentioning

confidence: 99%