Die Amnesie nach den Benzodiazepinen Flunitrazepam und Lorazepam

Heipertz, W; Vontin, H.; Schorer, Raoul; Junger, H.

doi:10.1007/978-3-642-67022-0_15

Cited by 4 publications

(5 citation statements)

References 3 publications

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“…In addition to sedative or hypnotic effects, many benzodiazepines produce varying de grees of antirecall properties, especially after intravenous administration [1], Degree and duration are dose-and age-related and differ ent for various benzodiazepines [14].…”

Section: Discussionmentioning

confidence: 99%

“…Drug or placebo was taken orally in identical capsules at 10 p.m. every evening for 28 days accord ing to a double-blind randomized crossover design: The subjects slept at home. 11 h after drug intake on days 1,7,8,14,15,21,22 and 28 (i.e. the first and last day in each period), after having had a normal breakfast, the sub jects reported to the laboratory where they were tested on a battery of psychological tests.…”

Section: Study 1: Residual Effects Of Single and Repeated Doses Of Zpmentioning

confidence: 99%

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Effects of Hypnotics on Memory

Fossen¹,

Godlibsen²,

Løyning³

et al. 1983

Pharmacology

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The influence on memory of 7.5 mg zopiclone, given in single and repeated doses was compared with that of 2 mg flunitrazepam, 5 mg nitrazepam and placebo. Compared with placebo, all three drugs induced some impairment of memory especially after the first day of administration. Effects were more pronounced for the two benzodiazepines and more marked for flunitrazepam. There was one report of an anterograde amnestic episode after flunitrazepam.

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Section: Discussionmentioning

confidence: 99%

Section: Study 1: Residual Effects Of Single and Repeated Doses Of Zpmentioning

confidence: 99%

Effects of Hypnotics on Memory

Fossen¹,

Godlibsen²,

Løyning³

et al. 1983

Pharmacology

View full text Add to dashboard Cite

show abstract

“…Lorrnetazepam und Flunitrazepam waren schon mehrfach Gegenstand von Studien, in denen Anxiolyse, Sedierung und Amnesie nach beiden Pharmaka untersucht wurden (1,2,6,7,8,11,12,15,18). Bei den vergleichenden Studien waren sie in gleicher rng/kg-Dosierung verabreicht worden (4,6,12,17 Stimmungslage (6, 15).…”

Section: Diskussionunclassified

“…Bei den vergleichenden Studien waren sie in gleicher rng/kg-Dosierung verabreicht worden (4,6,12,17 Stimmungslage (6, 15). Ebenso bedeutete Sedierung nicht zwangsläufig Amnesie (7,8). Nach unseren Befunden muß jetzt zusätzlich davon ausgegangen werden, daß nach Gewicht dosierte, vergleichbare Benzodiazepinmengen sehr unterschiedlich hohe Plasmakonzentrationen bewirken können.…”

Section: Diskussionunclassified