Die Bedeutung des Coeruloplasmins für die Differenzialdiagnose neuropsychiatrischer Störungen

Abstract

The blue copper protein ceruloplasmin has been of interest to psychiatrists for decades following Heilmeyer's observation of elevated serum copper levels in schizophrenic patients. Immunoturbidimetry, however, does not yield elevated serum ceruloplasmin concentrations in schizophrenia while ceruloplasmin-related oxidase activity appears to be elevated in patients with schizophrenia and reduced in patients with Alzheimer's disease. Low serum concentrations of immuno-turbidimetrically measured ceruloplasmin, and of oxidase activity, are typical of Wilson's disease, Menkes' disease, and aceruloplasminemia, three familial neurodegenerative disorders of pronounced variability, with regard to both genotype and phenotype. Especially patients with Wilson's disease may exhibit behavioural symptoms only over a long period. Heterozygous carriers of Wilson's disease and aceruloplasminaemia may have low serum ceruloplasmin concentrations; they will not develop somatic symptoms, but the significance of these carrier states, or of "hypoceruloplasminaemia", with regard to mental disorders is unknown.

Trace Elements Concentrations Association With Schizophrenia Symptoms; A Cross-Sectional Study in Croatia

“…Score plot of the 1 st BE and BPRS canonical variates; dotted line represents the moving median with 5 rows step Our finding of negative correlation of copper (Cu) concentration with total BPRS and negative symptoms was in line with the findings of Wang 1988, Zhai 1990, Luo 1991. It was different to Rahman et al 2009 andConnemann et al 2010 finding that the concentration of copper (Cu) is increased in patients diagnosed with schizophrenia compared to the healthy population. Finally, in Tada et al 1986 study no significant differences in copper (Cu) concentration was found between patients with schizophrenia and healthy control.…”

Serumcoeruloplasmin in einer randomisierten Bevölkerungsstichprobe mit 2 445 Probanden

“…Wenn dieser Einbau gestört ist, entsteht ein wenig stabiles Apoprotein. Aufgrund der unterschiedlichen Halbwertszeiten dieser beiden Fraktionen stellt sich im Serum ein Konzentrationsverhältnis von etwa zehn zu eins (Coeruloplasmin:Apocoeruloplasmin) ein, sodass das Gesamtcoeruloplasmin im Serum normalerweise vorwiegend von der hepatischen Kupferreserve abhängt (5).…”