Die Bedeutung von Muskelarbeit und -training für die Therapie des Diabetes mellitus^*1

Mobilization of subcutaneously injected tritiated insulin in rats: Effects of muscular exercise

“…Most probably due to anatomical differences, the time courses of both absorption and biological effect of subcutaneously injected insulin are considerably faster in rats than in humans; nevertheless, an analogous exercise-induced elevation of plasma [3H]insulin up to 90 min after its subcutaneous injection was recently observed by us in juvenile type diabetics [25]. It is, therefore, conceivable that these findings, which are in accordance with recent studies in dogs and man [3,4,5,6], represent a mechanism of exercise-induced hypoglycaemia in insulin treated diabetic patients.…”

“…Such a possibility has been proposed since physical activity increases the hypoglycaemic effect of subcutaneously injected insulin in humans with and without diabetes mellitus [ 1,2], a phenomenon which was entirely reproducible in normal rats during and after treadmill running, following the administration of a pharmacological dose of regular unlabelled insulin ( Figure 1). Based on experiments with pan-createctomized dogs [3] and diabetic patients [4,5,6], it was suggested that exercise accelerates the mobilization of subcutaneously injected insulin. But studies in humans using external counting to measure the effect of physical activity on the absorption of iodinated insulin, led to conflicting results [19,20,6].…”

Metabolic and hormonal effects of muscular exercise in juvenile type diabetics

“…Major differences in the status of training were ruled out. It has been suggested that the metabolic effects of exercise in diabetics can be masked by an increased mobilization of subcutaneously injected insulin induced by the contractions and/or concomitant circulatory changes [6,35,46]. Hence, in previous investigations, a distinction between the genuine metabolic effects of exercise and a possible exercise -induced potentiation of injected insulin was impossible [13,38,41].…”

Effect of physical training on glucose tolerance and on glucose metabolism of skeletal muscle in anaesthetized normal rats

“…Although physical activity is generally recommended for patients with diabetes mellitus [1,2,3] a positive effect of training on glucose tolerance has so far not been documented. While it is well known that immobilisation leads to an impairment of glucose tolerance in man [4,5] and in animals [5], even after long-term physical training the glucose tolerance…”