Die Behandlung des malignen Exophthalmus durch totale Thyreoidektomie

Müller, W; Schemmel, K.; Uthgenannt, H; Weissbecker, L

doi:10.1055/s-0028-1106097

Cited by 14 publications

(3 citation statements)

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“…At present, the treatment either attempts to modify the immunologic process or to correct the local damage surgically. The effect of thyroid surgery on the course Of endocrine ophthalmopathy is particularly controversial [5][6][7]. The aim of our prospective study was, therefore, to determine the influence of subtotal thyroidectomy on endocrine ophthalmopathy.…”

mentioning

confidence: 98%

The influence of surgery on endocrine ophthalmopathy

Frilling

Grußendorf

et al. 1990

World j. surg.

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Since the pathogenesis of endocrine ophthalmopathy is unclear, there has been little agreement on the treatment of the disease. The influence of thyroid surgery on endocrine ophthalmopathy is controversial. To evaluate the effect of thyroid surgery on the course of the disease, we developed a special ophthalmopathy index. As a standard procedure, subtotal thyroidectomy with thyroid remnants of 3-5 g was performed. A total of 176 patients with Graves' disease underwent the above treatment between 1986 and 1988. In 78 patients suffering from concomitant endocrine ophthalmopathy, ocular status was examined prior to operation and postoperatively. The history of endocrine ophthalmopathy had been present less than 2 years preoperatively in 74% of the patients. Follow-up ranged from 6 to 36 months. Postoperatively, 54 (69%) patients showed a marked improvement of their eye symptoms. In 18 (23%), there was no change and, in 6 (8%) patients, the severity of the eye symptoms increased after the operation. As a result of these data, a cautious and preliminary conclusion may be justified--that subtotal thyroidectomy may have a positive effect on endocrine ophthalmopathy.

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mentioning

confidence: 98%

The influence of surgery on endocrine ophthalmopathy

Frilling

Grußendorf

et al. 1990

World j. surg.

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“…Aueh wird fiber Patienten berichtet, deren maligne e.O. im Rahmen einer Hyperthyreose sich durch totale Thyreoidektomie zurfickbildete [7,40,49]. Auf diese Weise wurde die Aufmerksamkeit auf die Schilddrfise als urs&chlich beteiligtem Organ gelenkt.…”

Section: Diskussionunclassified

“…nachweisbar [6,45]. Oft sehwanden hohe LATS-Titer wie auch die Augensymptome nach totaler Thyreoidektomie [7,40]. Die pathogenetische Beziehung zwischen LATS und e.O.…”

Section: Diskussionunclassified

Zur Problematik der subtotalen Strumaresektion bei Hyperthyreose mit endokriner Ophthalmopathie

Schümann

Grabs

1975

Langenbecks Arch Chiv

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Observation of 39 patients who had undergone surgery for hyperthyroidism with or without endocrine ophthalmopathy between 1965 and 1972 indicate that this type of therapy involves no higher risk than do medication of radiological measures as far as the course of ophthalmic changes is concerned. Examination of the basal and the TRH-stimulated TSH concentrations i.s. argues against any primarily pituitary cause for progressive ophthalmopathy after surgery. In addition, it elucidates the almost inevitable postoperative development of preclinical hypothyroidism while the clinical condition is still euthyroid, and indicates the necessity of constant postoperative hormone substitution.

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