Die Cytogenese bei der Virus-Leukämie des Huhnes

An Unstable Haemoglobin Associated with Some Cases of Leukaemia

“…Thorell and his associates, using a inicrospectrographic method, have studied pathological haenloglobin formation in the leukaemic cells of virus-induced chicken erythroleukaemia. In the affected birds (Ambs and Thorell, 1959), and in a single case of human erythroleukaemia, haernoglobin formation was observed in the cytoplasm of primitive cells not normally forining it, in contrast to human acute leukaemic lymphoblasts and acute myeloleukaemia of the fowl (Cowles, Saikkonen and Thorell, 1958). No pathogenetic connection was stressed, but it is evident that considerable interest attaches to haemoglobin formation in leukaemia.…”

“…The cases of leukaemia and of Hb-H disease were examined for the presence of foetal haemoglobin (Hb-F) by a combined alkaline denaturation/ spectrographc procedure (Beaven, Ellis and White, 1960), sensitive to I per cent Hb-F. Of the three leukaemia cases -3.5 per cent Hb-F was found in Case I prior to transfusion, but was absent in the son; 9 per cent…”

The Histogenesis and Haematology of Virus-Induced Myeloid Leukaemia in the Fowl

“…A number of studies have been made in the past on the histo genesis and development of virus-induced erythroleukaemia in the fowl (1,3,5,8,9,10). Myeloid leukaemia, on the other hand, has received less attention in this respect in spite of the many virological and biochemical investigations performed regarding this disease.…”