Die Differentialdiagnose der Erythrocyth�mien durch Untersuchung der Ferround Erythrocytenkinetik mit radioaktivem Eisen und Chrom

Brunner, H. E.

doi:10.1007/bf01483848

Cited by 6 publications

(3 citation statements)

References 43 publications

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“…As has been previously observed, increased haemolysis was usual, but exceeded 4%/d in only 20% of cases as also noted in smaller series (Fundenberg & Mahoney, 1956;Meeus-Bith et al, 1957;Nathan & Berlin, 1959;Bowdler, 1961;Pitcock et al, 1962;Oettgen & Pribilla, 1964;Brunner, 1965;Gardner & Nathan, 1966;Desse-Elias et al, 1968;Storti & Perugini, 1968;Huber et al, 1969;Ward & Block, 1971;Milner et al, 1973;Christensen, 1975;Silverstein, 1975). This is of some importance since haemolysis is often used as an indication for splenectomy (for instance in the PVSG protocol for myelofibrosis).…”

Section: Erythrokinetic Abnormalitiessupporting

confidence: 67%

“…Quantitative defect of erythropoiesis, as evaluated by PIT (Huff et al, 195 I;Bothwell et al, 1957), is therefore not the cause of anaemia, even in cases with osteomyelosclerosis. O n the other hand, dyserythropoiesis appears to be very frequent in MF, as evidenced by the excessive plasma iron clearance with a low iron incorporation into the red cells (Nathan & Berlin, 1959;Bowdler, 1961;Szur & Smith, 1961;Oettgen & Pribilla, 1964;Brunner, 1965;Gardner & Nathan, 1966;Kesse-Elias et al, 1968;Huber et al, 1969;Lynch et al, 1969;Finch et al, 1970;Schulz et al, 1970;Milner et al, 1973). Surface count patterns, showing in many cases rapid and high splenic 59Fe uptake, and delayed and incomplete release, is other evidence of dyserythropoiesis (Turpin et al, 1971).…”

Section: Erythrokinetic Abnormalitiesmentioning

confidence: 99%

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Erythrokinetic Studies in Myelofibrosis: Their Significance for Prognosis

et al. 1978

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Eighty-three patients with myelofibrosis have been studied by erythrokinetics and have been followed up until death or for at least 12 months. Because of a large plasma volume the venous haematocrit gives only a poor idea of the red blood cell volume. The red cell survival was reduced in the majority of cases but significant haemolysis was rare. The amount of haemolysis of autologous and isologous red cells was similar, suggesting an extra-corpuscular origin for the haemolysis. Plasma iron turnover was always increased, sometimes markedly, but red cell iron incorporation was reduced in 70% of cases, indicating ineffective erythropoiesis. Surface counting showed an absence on diminution of sacral iron fixation and a rapid and marked splenic uptake in more than 90% of the cases; uptake of iron by the liver occurred in half the cases, usually not very high; iron release from the spleen was absent or reduced in 67% of the cases. The degree of ineffective erythropoiesis as measured by radio-iron incorporation and release by the spleen, the amount of haemolysis, and the red cell volume were strongly correlated with prognosis. These factors enabled a more precise prediction to be made of the clinical outcome in the 2 years following the study, than the clinical data alone. A prospective study might show whether erythrokinetic studies are also useful in determining the choice of treatment.

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Section: Erythrokinetic Abnormalitiessupporting

confidence: 67%

Section: Erythrokinetic Abnormalitiesmentioning

confidence: 99%

Erythrokinetic Studies in Myelofibrosis: Their Significance for Prognosis

et al. 1978

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“…Durch Inkubation mit radioaktivem Natriumchromat (Na251C r 0 1) können daher Erythrocyten signiert, nach intravenöser Injektion das Erythrocytenvolumen ge mäß dem Verdünnungsprinzip berechnet und durch Verfolgung der Radioaktivität im Blut die Lebensdauer der Erythrocyten bestimmt werden (6,7,8,10,13,25). Die Mar kierung kann in vivo durch direkte intravenöse Injektion der radioaktiven Chromver bindung, in vitro durch Zugabe des Na2!,1C r0 1 zu konzentrierten, im eigenen Plasma sus pendierten Erythrocyten oder zu ungerinnbar gemachtem Vollblut erfolgen.…”

Section: Untersuchung Der Erythrocytenkinetik Mit Cr61 A) Bestimmung unclassified