Die Druckanstiegsgeschwindigkeit im linken Ventrikel als Ma� f�r die Kontraktilit�t unter verschiedenen h�modynamischen Bedingungen

Morgenstern, C.; Arnold, G.; Höljes, U; Lochner, W.; Oswald, S.

doi:10.1007/bf00586659

Cited by 33 publications

(6 citation statements)

References 5 publications

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“…More recently, unanimity of opinion was broken somewhat by the observation of F urnival et al [5] that changes in LVEDP were not accompanied by alterations in dP/dtmax when mean arterial pressure was held constant in the open-chest dog; they did confirm that an increase in mean arterial pressure was accompanied by an increase in dP/dt,".,x. Morgenstern et al [10] observed that, when dP/dt,,,.1X occurred during the isovolumic phase, LVEDP and coronary perfusion pressure, but not aortic pressure, altered the magnitude of dP/dt,,,ax. Both observers did agree that these hemodynamically induced effects were small compared to those evoked by infusion of positive inotropic agents.…”

Section: Discussionmentioning

confidence: 99%

Concurrent Measurement of Left Ventricular dP/dt<sub>max</sub>, Isometric Contractile Force and Cardiac Loading in the Intact Monkey

Randall¹

1974

Cardiology

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Eight rhesus monkeys were implanted with catheters to measure left ventricular and arterial pressure; an isometric strain gauge was sutured onto the myocardium in four of them. The maximum rate of rise of ventricular pressure (dP/dt_maχ) and left ventricular force of contraction (LVF) were determined during positive inotropic responses elicited by administration of isoproterenol and by several controlled behavioral situations. Both dP/dt and LVF increased concomitantly during the testing situations; linear correlation coefficients relating the variables typically exceeded 0.8 (p < 0.01). The possible influence of altered loading conditions on dP/dt was investigated in four animals after surgical denervation of their hearts to eliminate direct neural reflex effects. Arterial pressure and left ventricular filling pressure were increased by infusion of phenylephrine and decreased by nitroglycerine. Alterations in loading did not exert any significant influence on dP/dt_maχ in the intact monkey with a denervated heart.

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Section: Discussionmentioning

confidence: 99%

Concurrent Measurement of Left Ventricular dP/dt<sub>max</sub>, Isometric Contractile Force and Cardiac Loading in the Intact Monkey

Randall¹

1974

Cardiology

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“…To assess the effects of the possible role of alterations in sympathetic tone in these conscious dogs (5,6,(8)(9)(10). Thus, the response to isoproterenol has been a uniform augmentation of peak (+) dP/dt, whereas peak (-) dP/dt remained either unchanged (1,5), or declined (9, 10).…”

Section: Interventions Before and After Beta-adrenergic Blockadementioning

confidence: 99%

“…The Journal of Clinical Investigation Volume 60 September 1977 511-521 511 (1,(8)(9)(10), while acutely induced increases in left ventricular or aortic systolic pressure, which either reduce or exert little effect on peak (+) dP/dt, tend to augment peak (-) dP/dt (1,6). Therefore, in the present study we examined the influence of several acute pharmacologic and mechanical interventions on isovolumic relaxation in the normal conscious dog by employing infusions of isoproterenol, phenylephrine, or calcium, and by atrial pacing and its abrupt cessation.…”

Section: Introductionmentioning

confidence: 99%

Pharmacologic and Hemodynamic Influences on the Rate of Isovolumic Left Ventricular Relaxation in the Normal Conscious Dog

Karliner¹,

LeWinter²,

Mahler³

et al. 1977

J. Clin. Invest.

231

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A B S T R A C T We studied the effects of acute pharmacologic and hemodynamic interventions on isovolumic left ventricular relaxation in 19 conscious dogs using micromanometer tip catheters. Isoproterenol (11 studies) augmented peak rate of rise of left ventricular pressure [(+) dP/dt] by 1,275+227 (SE) mm Hg/s (P < 0.001) and dP/dt at an isopressure point of 35 mm Hg during isovolumic relaxation [(-) dP/dt35] by 435±80 mm Hg/s (P < 0.001). Peak (-) dP/dt decreased by 467±89 mm Hg/s (P < 0.002). The time constant, T, derived from the logarithmic fall ofpressure during isovolumic relaxation, shortened from 20±2.8 to 14.9± 1.8 ms (P < 0.003). Calcium ( 11 studies) increased peak (+) dP/dt and (-) dP/dt35 (both P <0.0001); peak (-) dP/dt was unchanged. T shortened from 20.4±1.8 to 17.3±1.5 ms (P < 0.002). Volume (13 studies) did not affect either dP/dt or T. Phenylephrine (13 studies) augmented peak (-) dP/dt, but reduced (-) dP/dt35 (both P < 0.01); T lengthened from 22.1±1.5 to 32.5±1.5 ms (P < 0.01). In 15 studies, rapid atrial pacing increased peak (+) dP/dt and (-) dP/dt35 (both P < 0.01). In the first post-pacing beat, peak (-) dP/dt and (-) dP/dt35 decreased (both P <0.01), although peak (+) dP/dt increased furtier. T paralleled values of (-) dP/dt35. In five dogs, beta

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“…It is generally recognized that LV dDIdtntar is more sensitive to changes in afterload (1), while LV dPldtmar is thought to be more sensitive to changes in preload (2). The concept of preload de-pendency of LV dPldtmax is based on numerous studies in isolated cardiac muscle (3)(4)(5)(6), isolated hearts (6)(7)(8)(9)(10)(11), anesthetized dogs (11)(12)(13)(14)(15)(16) and even intact, conscious dogs (17), and man (18). The conceptual basis for the preload dependency of LV dPldtmar is that an increase in preload activates the Frank-Starling mechanism, which in turn, increases LV dP/dtmar…”

Section: Introductionmentioning

confidence: 99%

Effects of Acute Increases in Left Ventricular Preload on Indices of Myocardial Function in Conscious, Unrestrained and Intact, Tranquilized Baboons

Zimpfer¹,

Vatner²

1981

J. Clin. Invest.

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A B S T R A C T The effects of acute volume loading were examined on indices of left ventricular (LV) function in conscious, unrestrained and intact, tranquilized baboons. Experiments were conducted 1-3 mo after implantation of ultrasonic transducers to measure LV internal diameter and wall thickness, and miniature LV pressure gauges and aortic and left atrial catheters. In 10 intact, tranquilized baboons, rapid volume loading with saline increased LV end-diastolic pressure by 23.7 ±2.6 mm Hg, LV end-diastolic diameter by 7.8±1.5%, LV stroke work by 37.5±7.8%, while mean arterial pressure and peak LV wall stress did not change significantly. Despite the increase in preload and activation of the Frank-Starling mechanism, LV dPldtmar and the maximum velocity of myocardial fiber shortening (LV dD/ dtmax) did not change. Volume loading afterf/-adrenergic or combined 3-adrenergic and cholinergic blockades or volume loading with blood instead of saline also failed to augment LV dP/dt max and LV dDIdt max despite the increase in preload. In order to volume load the baboons in the conscious state, a radiofrequency (RF) interrogator system was devised, which upon receipt of a radio command, activated a battery operated pump to infuse 1,000 ml of saline i.v. to the baboons. In these experiments, preload rose, i.e., LV end-diastolic diameter increased by 13

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Die Druckanstiegsgeschwindigkeit im linken Ventrikel als Ma� f�r die Kontraktilit�t unter verschiedenen h�modynamischen Bedingungen

Cited by 33 publications

References 5 publications

Concurrent Measurement of Left Ventricular dP/dt<sub>max</sub>, Isometric Contractile Force and Cardiac Loading in the Intact Monkey

Concurrent Measurement of Left Ventricular dP/dt<sub>max</sub>, Isometric Contractile Force and Cardiac Loading in the Intact Monkey

Pharmacologic and Hemodynamic Influences on the Rate of Isovolumic Left Ventricular Relaxation in the Normal Conscious Dog

Effects of Acute Increases in Left Ventricular Preload on Indices of Myocardial Function in Conscious, Unrestrained and Intact, Tranquilized Baboons

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